Histomorphological Studies of the Organs of Malaria Mice Model After Administration Combination of Leaf and Stem Bark Extract of Syzygium cumini with Chloroquine

• Main Authors: Lilik Maslachah, -, Lucia Tri Suwanti, -, Hardany Primarizky, -, Thomas Valentinus Widiyatno, -, Dyah Fitria Ratna Kusuma, -, Ridhofajuri Winanda, -, Ryandika Wahyu Prasetyo, -
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Indian Journal of Forensic Medicine & Toxicology 2020
• Subjects: SF405.5-407 Laboratory animals; SF811-909 Veterinary medicine of special organs, regions, and systems
• Online Access: https://repository.unair.ac.id/104342/5/Bukti%20C06_Histomorphological%20Studies%20of%20the%20Organs%20of%20Malaria%20Mice%20Model%20After%20Administration%20Combination%20of%20Leaf%20and%20Stem%20Bark%20Extract%20of%20Syzygium%20cumini%20with%20Chloroquine.pdf; https://repository.unair.ac.id/104342/3/Peer%20review%20C06_Histhomorphological%20Studies%20of%20the%20Organs%20of%20Malaria%20Mice%20Model%20After%20Administration%20Combination%20of%20Leaf%20and%20Stem%20Bark%20Extract%20of%20Syzygium%20cumini%20with%20Choroquine.%20%28Penulis%20Pertama%29.pdf; https://repository.unair.ac.id/104342/1/C%2006.%20Histomorphological%20Studies%20of%20the%20Organs%20of%20....pdf; https://repository.unair.ac.id/104342/6/6.%20Histomorphological%20studies%20of%20the%20organs%20of%20malaria.pdf; https://repository.unair.ac.id/104342/
• Institution: Universitas Airlangga

This study aims to assess the histomorphological finding of the in spleen, brain, kidneys and lungs organ in malaria mice model after administration combination of Leaf and Stem bark extract of Syzygium cumini with chloroquine. Thirty-five male albinomice were randomly assigned into 7 treatment groups. K0: not infected, K1: infected. K2: infected+chloroquine. P1: infected+Syzygium cumini leaf extract. P2 : infected+chloroquine+Syzygium cumini leaf extract. P3: infected +Syzygium cumini stem bark extract. P4: infected +chloroquine+ Syzygium cumini stem bark extract. Therapy was given once a day for 4 days after 24 hours post infection. The 21stday, mice were euthanasia. The organs were taken in order to make histopathology preparations, stained with hematoxylin and eosin. The combination of Syzygium cumini leaf extract and chloroquine in mice infected with P. berghei can reduce cerebrum and cerebellum microglia cell counts, white pulp diameter size, haemorrhages damage, alveolar congestion, edema and thickened alveolar septa of lung, decreased tubular necrosis, and interstitial nephritis of renal Keywords: chloroquine, histomorphological, mice, P. berghei, Syzygium cumini