Potensi Ekstrak Rumput Kebar (Biophytum petersianum) terhadap Gambaran Histopatologi Ginjal Anak Mencit (Mus musculus) Pada Masa Laktasi Dari Induk yang Dipapar Karbofuran

• Main Author: Ernestine Sisca Priyatna, -
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; English; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian
• Published: 2020
• Subjects: SF780.2-780.7 Veterinary microbiology, bacteriology, virology, mycology; SF811-909 Veterinary medicine of special organs, regions, and systems
• Online Access: http://repository.unair.ac.id/104657/1/1.%20HALAMAN%20JUDUL.pdf; http://repository.unair.ac.id/104657/2/2.%20ABSTRACT.pdf; http://repository.unair.ac.id/104657/3/3.%20DAFTAR%20ISI.pdf; http://repository.unair.ac.id/104657/4/4.%20BAB%201%20PENDAHULUAN.pdf; http://repository.unair.ac.id/104657/5/5.%20BAB%202%20TINJAUAN%20PUSTAKA.pdf; http://repository.unair.ac.id/104657/6/6.%20BAB%203%20MATERI%20DAN%20METODE.pdf; http://repository.unair.ac.id/104657/7/7.%20BAB%204%20HASIL%20PENELITIAN.pdf; http://repository.unair.ac.id/104657/8/8.%20BAB%205%20PEMBAHASAN.pdf; http://repository.unair.ac.id/104657/10/9.%20BAB%206%20KESIMPULAN.pdf; http://repository.unair.ac.id/104657/9/10.%20DAFTAR%20PUSTAKA.pdf; http://repository.unair.ac.id/104657/11/11.%20LAMPIRAN.pdf; http://repository.unair.ac.id/104657/12/KH.14-21-EMBARGO%20%5BErnestine%20S%5D%20-%20ernest%20sisca.pdf; http://repository.unair.ac.id/104657/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

This aims of this research is to know about the potential of kebar grass extract in reducing the impact of kidney damage in mice offspring during lactation period from parent exposed to carbofuran. Carbofuran, kebar grass extract, and vitamin C are exposed orally postnatal day 1st until 14th postnatal day after delivery. Mice adult in lactation period were randomly into seven groups. This group consisted of K (aquadest control), P1 (carbofuran ¼ LD50 0.0125 mg/day), P2 (carbofuran 1/8 LD50 0.00625 mg/day), P3 (kebar grass extract 3.375 mg + carbofuran ¼ LD50), P4 (kebar grass extract 3.375 mg + carbofuran 1/8LD50), P5 (vitamin C 0.2 cc + carbofuran ¼ LD50), and P6 (vitamin C 0.2 cc + carbofuran 1/8 LD50). On the 15th days of the experiment, offspring were randomly selected and dissected and the kidney which was taken to made histopathology sample. The result of this study carbofuran caused increased tubular degeneration, necrosis, and inflammation. The result showed significant different (p<0,05) among the treatment groups. Mean of P4 in degeneration is (0,80), necrosis (0,86), and inflammation (0,86), while the mean of P6 in degeneration is (2,06), necrosis (2,06), and inflammation (1,93). The conclusion is giving Kebar grass extract is more effective than vitamin C in reducing kidney damage in mice offspring during lactation period from parent exposed to carbofuran.