Aktivitas Antivirus Hepatitis C Ekstrak Etanol 96%, N-Heksana, dan Fraksinya Dari Daun Kemuning (Murraya Paniculata (L.) Jack) In Vitro

• Main Author: Noor Annisa Mones
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian
• Published: 2020
• Subjects: RS Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/104755/1/1.%20HALAMAN%20JUDUL.pdf; http://repository.unair.ac.id/104755/2/2.%20ABSTRACT%20.pdf; http://repository.unair.ac.id/104755/3/3.%20DAFTAR%20ISI%20.pdf; http://repository.unair.ac.id/104755/4/4.%20BAB%20I%20PENDAHULUAN.pdf; http://repository.unair.ac.id/104755/5/5.%20BAB%20II%20TINJAUAN%20PUSTAKA.pdf; http://repository.unair.ac.id/104755/6/6.%20BAB%20III%20KERANGKA%20KONSEPTUAL.pdf; http://repository.unair.ac.id/104755/7/7.%20BAB%20IV%20METODE%20PENELITIAN.pdf; http://repository.unair.ac.id/104755/8/8.%20BAB%20V%20HASIL%20PENELITIAN%20DAN%20PEMBAHASAN.pdf; http://repository.unair.ac.id/104755/9/9.%20BAB%20VI%20KESIMPULAN%20DAN%20SARAN.pdf; http://repository.unair.ac.id/104755/10/10.%20DAFTAR%20PUSTAKA%20.pdf; http://repository.unair.ac.id/104755/11/11.%20LAMPIRAN%20.pdf; http://repository.unair.ac.id/104755/12/12.%20EMBARGO.pdf; http://repository.unair.ac.id/104755/; http://www.lib.unair.ac.id
• Institution: Universitas Airlangga

Murraya paniculata (L.) Jack is a plant of Rutaceae’s family which is commonly called kemuning. Previous preclinical and clinical studies showed that M. paniculata (L.) Jack leaf extract possess hepatoprotective activity because it can reduce levels of SGOT and SGPT. In the present study, ethanolic extract, n-hexane extract and fractions (dichloromethane and methanolic) of M. paniculata (L.) Jack were tested in vitro study using Huh7it cells against hepatitis C virus. The results indicated that ethanolic extract, n-hexane extract, dichloromethane fraction and methanolic fraction of this plant mediated antihepatitis C virus activity with the IC50 value of as 42.29 ± 4.53 μg/mL; 11.44 ± 4.42 μg/mL; 1.91 ± 0.42 μg/mL; and 2.26 ± 0.43 μg/mL, respectively. A cytotoxicity test was conducted and the results showed the CC50 of the ethanolic extract was 76.35 ± 6.67 μg/mL. It indicated a moderate toxic of ethanolic extract. Further study were needed to evaluate the active compounds of n-hexane extract and fractions (dichloromethane and methanolic) which possessed antiviral activity.