The Efficacy of topical Combination Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E after Microneedling in Photoaging
Background: Photoaging, also called extrinsic aging, is a premature skin aging mainly resulting from prolonged and extended exposure to ultraviolet (UV) radiation. Amniotic Membrane Stem Cell Metabolite Products (AMSC-MP) are derived from amniotic membranes that contain cytokines and growth factors...
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Fakultas Kedokteran Universitas Airlangga
2020
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id-langga.1054712021-04-15T06:58:36Z http://repository.unair.ac.id/105471/ The Efficacy of topical Combination Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E after Microneedling in Photoaging Agatha Anindhita Ayu Ardhaninggar Dwi Murtiastutik Sawitri Cita Rosita Sigit Prakoeswa R Medicine (General) RL Dermatology Background: Photoaging, also called extrinsic aging, is a premature skin aging mainly resulting from prolonged and extended exposure to ultraviolet (UV) radiation. Amniotic Membrane Stem Cell Metabolite Products (AMSC-MP) are derived from amniotic membranes that contain cytokines and growth factors that have a role in the skin rejuvenation process. Vitamin E is an antioxidant that has a photoprotective effect, so it is expected to reduce the appearance of clinical signs of photoaging. Not only having skin rejuvenation effect, but microneedling is also expected to facilitate the penetration to increase the efficacy of AMSC-MP and vitamin E. This combination is expected to have a better effect on clinical photoaging improvement. Purpose: To evaluate the effect of a topical combination of AMSC-MP and vitamin E after microneedling on the clinical improvement of photoaging compared to previous skin conditions. Methods: Thirty adult women with photoaging topically administered a combination of AMSC-MP and vitamin E after 3 microneedling sessions at 2 weeks intervals. The evaluation of the improvement of the degree of pores, wrinkles, skin tone and dark spots were performed with the Janus-II Facial Skin Scope System. Result: There was a clinical improvement with a statistically significant difference in terms of the degree of pores, wrinkles, polarized black spots, and UV black spots, which were statistically significant differences (p <0.05). Conclusion: The administration of a topical combination of AMSC-MP and vitamin E after microneedling provided clinical improvement in photoaging as supported by the results of Janus analysis of pores, wrinkles, skin tones, polarized black spots, and UV black spots. Fakultas Kedokteran Universitas Airlangga 2020 Article PeerReviewed text en http://repository.unair.ac.id/105471/1/The%20Efficacy%20of%20Topical%20Combination%20Amniotic%20Membrane%20Stem%20Cell%20Metabolite%20Product%209AMSC-MP%29%20and%20Vitamin%20E%20after%20Microneedling%20in%20Photoaging%20.pdf text en http://repository.unair.ac.id/105471/2/The%20Efficacy%20of%20Topical%20Combination.pdf text en http://repository.unair.ac.id/105471/3/The%20Efficacy%20of%20Topical%20Combination%20Amniotic%20Membrane%20Stem%20Cell%20Metabolite%20Product%209AMSC-MP%29%20and%20Vitamin%20E%20after%20Microneedling%20in%20Photoaging.pdf Agatha Anindhita Ayu Ardhaninggar and Dwi Murtiastutik and Sawitri and Cita Rosita Sigit Prakoeswa (2020) The Efficacy of topical Combination Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E after Microneedling in Photoaging. Berkala Ilmu Kesehatan Kulit dan Kelamin, 32 (3). pp. 126-133. ISSN 19784279 https://e-journal.unair.ac.id/BIKK/article/view/16064 http://dx.doi.org/10.20473/bikk.V32.2.2020.126-133 |
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R Medicine (General) RL Dermatology Agatha Anindhita Ayu Ardhaninggar Dwi Murtiastutik Sawitri Cita Rosita Sigit Prakoeswa The Efficacy of topical Combination Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E after Microneedling in Photoaging |
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Background: Photoaging, also called extrinsic aging, is a premature skin aging mainly resulting from prolonged and extended exposure to ultraviolet (UV) radiation. Amniotic Membrane Stem Cell Metabolite Products (AMSC-MP) are derived from amniotic membranes that contain cytokines and growth factors that have a role in the skin rejuvenation process. Vitamin E is an antioxidant that has a photoprotective effect, so it is expected to reduce the appearance of clinical signs of photoaging. Not only having skin rejuvenation effect, but microneedling is also expected to facilitate the penetration to increase the efficacy of AMSC-MP and vitamin E. This combination is expected to have a better effect on clinical photoaging improvement. Purpose: To evaluate the effect of a topical combination of AMSC-MP and vitamin E after microneedling on the clinical improvement of photoaging compared to previous skin conditions. Methods: Thirty adult women with photoaging topically administered a combination of AMSC-MP and vitamin E after 3 microneedling sessions at 2 weeks intervals. The evaluation of the improvement of the degree of pores, wrinkles, skin tone and dark spots were performed with the Janus-II Facial Skin Scope System. Result: There was a clinical improvement with a statistically significant difference in terms of the degree of pores, wrinkles, polarized black spots, and UV black spots, which were statistically significant differences (p <0.05). Conclusion: The administration of a topical combination of AMSC-MP and vitamin E after microneedling provided clinical improvement in photoaging as supported by the results of Janus analysis of pores, wrinkles, skin tones, polarized black spots, and UV black spots. |
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Article PeerReviewed |
author |
Agatha Anindhita Ayu Ardhaninggar Dwi Murtiastutik Sawitri Cita Rosita Sigit Prakoeswa |
author_facet |
Agatha Anindhita Ayu Ardhaninggar Dwi Murtiastutik Sawitri Cita Rosita Sigit Prakoeswa |
author_sort |
Agatha Anindhita Ayu Ardhaninggar |
title |
The Efficacy of topical Combination Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E after Microneedling in Photoaging |
title_short |
The Efficacy of topical Combination Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E after Microneedling in Photoaging |
title_full |
The Efficacy of topical Combination Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E after Microneedling in Photoaging |
title_fullStr |
The Efficacy of topical Combination Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E after Microneedling in Photoaging |
title_full_unstemmed |
The Efficacy of topical Combination Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E after Microneedling in Photoaging |
title_sort |
efficacy of topical combination amniotic membrane stem cell metabolite product (amsc-mp) and vitamin e after microneedling in photoaging |
publisher |
Fakultas Kedokteran Universitas Airlangga |
publishDate |
2020 |
url |
http://repository.unair.ac.id/105471/1/The%20Efficacy%20of%20Topical%20Combination%20Amniotic%20Membrane%20Stem%20Cell%20Metabolite%20Product%209AMSC-MP%29%20and%20Vitamin%20E%20after%20Microneedling%20in%20Photoaging%20.pdf http://repository.unair.ac.id/105471/2/The%20Efficacy%20of%20Topical%20Combination.pdf http://repository.unair.ac.id/105471/3/The%20Efficacy%20of%20Topical%20Combination%20Amniotic%20Membrane%20Stem%20Cell%20Metabolite%20Product%209AMSC-MP%29%20and%20Vitamin%20E%20after%20Microneedling%20in%20Photoaging.pdf http://repository.unair.ac.id/105471/ https://e-journal.unair.ac.id/BIKK/article/view/16064 http://dx.doi.org/10.20473/bikk.V32.2.2020.126-133 |
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