Calotetrapterins A-C, three new pyranoxanthones and their cytotoxicity from the stem bark of Calophyllum tetrapterum Miq

• Main Authors: Mulyadi Tanjung, Tjitjik Srie Tjahjandarie, Ratih Dewi Saputri, Baharrani Dwi Kurnia, Muhammad Faisal Rachman, Yana Maolana Syah
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Taylor & Francis 2019
• Subjects: Q Science; QD Chemistry
• Online Access: http://repository.unair.ac.id/105806/1/C01.%20Fulltext_Calotetrapterins%20A%20C%20three.pdf; http://repository.unair.ac.id/105806/4/C01.%20Validasi%20dan%20Review.pdf; http://repository.unair.ac.id/105806/3/C01.%20Similarity_Calotetrapterins%20A%20C%20three_.pdf; http://repository.unair.ac.id/105806/2/C01.%20Korespondensi.pdf; http://repository.unair.ac.id/105806/; https://www.tandfonline.com/doi/abs/10.1080/14786419.2019.1634714
• Institution: Universitas Airlangga

Three new pyranoxanthones, calotetrapterins A-C (1-3) were isolated from the stem bark of Calophyllum tetrapterum Miq along with three known xanthones, α-mangostin (4), garciniafuran (5), and pyranojacareubin (6). All structures were elucidated based on their IR, UV, HRESIMS, 1 D (1H, 13C) and 2 D (HMBC, HMQC) NMR spectral data. Compounds 1-6 were tested to P-388 cells for cytotoxic activity, compound 2 exhibited high activity with IC50 value 1.0 μM. (Graphical abstract)