The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients

• Main Authors: Brahmana Askandar, -, Trianggono Bagus Ariyanto, -, Indra Yuliati, -, Willy Sandhika, -
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Wolters Kluwer Medknow Publications 2020
• Subjects: R Medicine (General); RG Gynecology and obstetrics
• Online Access: https://repository.unair.ac.id/107635/1/The%20Role%20of%20lymph-vascular%20space%20invasion%20towards%20disease%20of%20free%20survival%20and%20overall%20survival%20cancer%20in%20high-risk%20endometrial%20cancer%20endometrioid%20type%20patients.pdf; https://repository.unair.ac.id/107635/2/The%20Role%20of%20Lymph.pdf; https://repository.unair.ac.id/107635/3/The%20Role%20of%20lymph-vascular%20space%20invasion%20towards%20disease%20of%20free%20survival%20and%20overall%20survival%20cancer%20in%20high-risk%20endometrial%20cancer%20endometrioid%20type%20patients.pdf; https://repository.unair.ac.id/107635/6/Bukti%20Etik%20No%202.pdf; https://repository.unair.ac.id/107635/; https://www.sysrevpharm.org/abstract/the-role-of-lymphvascular-space-invasion-towards-disease-of-free-survival-and-overall-survival-cancer-in-highrisk-endome-65686.html; http://dx.doi.org/10.5530/srp.2019.2.04
• Institution: Universitas Airlangga

Major prognostic factors of endometrial cancer include stage, age, histopathological type, grading, depth of invasion of myometrium, and presence of Lymph-vascular Space Invasion (LVSI). This study evaluated the LVSI in disease free survival (DFS) and overall survival (OS) in high-risk endometrial cancer endometrioid type. This was a retrospective study. Survival analysis using Kaplan-Maier curve, log rank test, cox-regression and logistic regression were used to determine effects among variables. Among fifty-six patients, 43% of patients were <60 years, 73% with BMI <30, 17% were multiparous, and 79% were menopausal patients. There were 32% of patients with positive LVSI. Most clinical stages were found in stage III with 31 cases (55%). Patients with positive LVSI had OS lower than patients with negative LVSI (50% vs 55.3%). There were no significant results of LVSI as prognostic factor for OS. Patients with LVSI positive had survival time of 26.5 months (20.5 – 32.5). There were no significant results of LVSI as prognostic factor for DFS. Patients with positive LVSI had lower DFS than patients with negative LVSI (81.8% vs 85.7%). There were significant results of LVSI as prognostic factor for high-risk endometrioid type endometrial cancer with stage endometrial cancer with p = 0.01. LVSI acts as prognostic factor for high-risk endometrioid type endometrial cancer associated with stage endometrial cancer. However, there was no effect in DFS and OS.