Testosteron Level and Insulin Resistance in Men With Type 2 Diabetes Mellitus-Metabolic Syndrome

Background: Testosterone deficiency often occurs in people with type 2 diabetes mellitus (T2DM) where it contributes to mood and libido disturbances. Total testosterone levels inversely associated with insulin resistance, a factor which has the potential to provide micro and macro vascular complicat...

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Main Authors: Askandar Tjokroprawiro, Hermawan Susanto, Sony Wibisono, Sri Murtiwi, Soebagijo Adi Soelistijo, Ari Sutjahjo, Agung Pranoto
Format: Article PeerReviewed
Language:English
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Published: Elsevier BV 2014
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Online Access:http://repository.unair.ac.id/108488/1/C-27.pdf
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https://www.diabetesresearchclinicalpractice.com/action/showPdf?pii=S0168-8227%2814%2970655-2
https://doi.org/10.1016/S0168-8227(14)70655-2
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spelling id-langga.1084882021-07-23T01:57:21Z http://repository.unair.ac.id/108488/ Testosteron Level and Insulin Resistance in Men With Type 2 Diabetes Mellitus-Metabolic Syndrome Askandar Tjokroprawiro Hermawan Susanto Sony Wibisono Sri Murtiwi Soebagijo Adi Soelistijo Ari Sutjahjo Agung Pranoto R Medicine (General) RC Internal medicine Background: Testosterone deficiency often occurs in people with type 2 diabetes mellitus (T2DM) where it contributes to mood and libido disturbances. Total testosterone levels inversely associated with insulin resistance, a factor which has the potential to provide micro and macro vascular complications in patients with T2DM. Several studies in men showed that testosterone supplementation can improve insulin sensitivity conditions. Recent studies have reported that 20–64% of men with testosterone deficiency/hypogonadism also have T2DM. The proportion of men who have both T2DM and hypogonadism increases in older groups of men. Men who have slightly reduced total testosterone level, but not low enough to be considered as testosterone deficiency are also more likely to have low insulin and high blood glucose levels. This study will examine the correlation between total testosterone level and insulin resistance in men with T2DMMetS. Method: This cross sectional study was performed in Surabaya private clinic. Study period was six months between January to June 2014. The variables include: fasting blood sugar, 1 hour post prandial, A1C, HOMA-IR and levels of the total testosterone was measured by radioimmunoassay technique. Low testosterone for patient with T2DM was defined as below 400 ng/dL and normal if above 400 ng/dL. HOMA-IR value more than 2.0 is considered to be positive for IR. Patients on testosterone replacement, and corticosteroids were excluded from this study. Statistical analysis was performed using SPSS 17.0 and Spearmen’s test. Result: Fifty two male subjects were enrolled in this study. The mean age was 62.32±8.72 years old, fasting blood sugar 139.68±43.65mg/dL, blood glucose 1 hour post prandial 255.56±112.06 mg/dL, mean A1C 7.89±1.80%, the mean HOMA-IR 7.14±4.77, while the mean testosterone levels 315.39±251.30 ng/dL. The statistical analysis showed inverse correlation between total testosterone levels and insulin resistance (r: −0.215, p: 0.034) Conclusion: There was a significant inverse correlation between total testosterone level and insulin resistance in this study. Elsevier BV 2014-11 Article PeerReviewed text en http://repository.unair.ac.id/108488/1/C-27.pdf text en http://repository.unair.ac.id/108488/2/C-27%20turnitin.pdf text en http://repository.unair.ac.id/108488/3/C-27%20kadep.pdf Askandar Tjokroprawiro and Hermawan Susanto and Sony Wibisono and Sri Murtiwi and Soebagijo Adi Soelistijo and Ari Sutjahjo and Agung Pranoto (2014) Testosteron Level and Insulin Resistance in Men With Type 2 Diabetes Mellitus-Metabolic Syndrome. Diabetes Research and Clinical Practice, 106 (Supp1). pp. 231-232. https://www.diabetesresearchclinicalpractice.com/action/showPdf?pii=S0168-8227%2814%2970655-2 https://doi.org/10.1016/S0168-8227(14)70655-2
institution Universitas Airlangga
building Universitas Airlangga Library
continent Asia
country Indonesia
Indonesia
content_provider Universitas Airlangga Library
collection UNAIR Repository
language English
English
English
topic R Medicine (General)
RC Internal medicine
spellingShingle R Medicine (General)
RC Internal medicine
Askandar Tjokroprawiro
Hermawan Susanto
Sony Wibisono
Sri Murtiwi
Soebagijo Adi Soelistijo
Ari Sutjahjo
Agung Pranoto
Testosteron Level and Insulin Resistance in Men With Type 2 Diabetes Mellitus-Metabolic Syndrome
description Background: Testosterone deficiency often occurs in people with type 2 diabetes mellitus (T2DM) where it contributes to mood and libido disturbances. Total testosterone levels inversely associated with insulin resistance, a factor which has the potential to provide micro and macro vascular complications in patients with T2DM. Several studies in men showed that testosterone supplementation can improve insulin sensitivity conditions. Recent studies have reported that 20–64% of men with testosterone deficiency/hypogonadism also have T2DM. The proportion of men who have both T2DM and hypogonadism increases in older groups of men. Men who have slightly reduced total testosterone level, but not low enough to be considered as testosterone deficiency are also more likely to have low insulin and high blood glucose levels. This study will examine the correlation between total testosterone level and insulin resistance in men with T2DMMetS. Method: This cross sectional study was performed in Surabaya private clinic. Study period was six months between January to June 2014. The variables include: fasting blood sugar, 1 hour post prandial, A1C, HOMA-IR and levels of the total testosterone was measured by radioimmunoassay technique. Low testosterone for patient with T2DM was defined as below 400 ng/dL and normal if above 400 ng/dL. HOMA-IR value more than 2.0 is considered to be positive for IR. Patients on testosterone replacement, and corticosteroids were excluded from this study. Statistical analysis was performed using SPSS 17.0 and Spearmen’s test. Result: Fifty two male subjects were enrolled in this study. The mean age was 62.32±8.72 years old, fasting blood sugar 139.68±43.65mg/dL, blood glucose 1 hour post prandial 255.56±112.06 mg/dL, mean A1C 7.89±1.80%, the mean HOMA-IR 7.14±4.77, while the mean testosterone levels 315.39±251.30 ng/dL. The statistical analysis showed inverse correlation between total testosterone levels and insulin resistance (r: −0.215, p: 0.034) Conclusion: There was a significant inverse correlation between total testosterone level and insulin resistance in this study.
format Article
PeerReviewed
author Askandar Tjokroprawiro
Hermawan Susanto
Sony Wibisono
Sri Murtiwi
Soebagijo Adi Soelistijo
Ari Sutjahjo
Agung Pranoto
author_facet Askandar Tjokroprawiro
Hermawan Susanto
Sony Wibisono
Sri Murtiwi
Soebagijo Adi Soelistijo
Ari Sutjahjo
Agung Pranoto
author_sort Askandar Tjokroprawiro
title Testosteron Level and Insulin Resistance in Men With Type 2 Diabetes Mellitus-Metabolic Syndrome
title_short Testosteron Level and Insulin Resistance in Men With Type 2 Diabetes Mellitus-Metabolic Syndrome
title_full Testosteron Level and Insulin Resistance in Men With Type 2 Diabetes Mellitus-Metabolic Syndrome
title_fullStr Testosteron Level and Insulin Resistance in Men With Type 2 Diabetes Mellitus-Metabolic Syndrome
title_full_unstemmed Testosteron Level and Insulin Resistance in Men With Type 2 Diabetes Mellitus-Metabolic Syndrome
title_sort testosteron level and insulin resistance in men with type 2 diabetes mellitus-metabolic syndrome
publisher Elsevier BV
publishDate 2014
url http://repository.unair.ac.id/108488/1/C-27.pdf
http://repository.unair.ac.id/108488/2/C-27%20turnitin.pdf
http://repository.unair.ac.id/108488/3/C-27%20kadep.pdf
http://repository.unair.ac.id/108488/
https://www.diabetesresearchclinicalpractice.com/action/showPdf?pii=S0168-8227%2814%2970655-2
https://doi.org/10.1016/S0168-8227(14)70655-2
_version_ 1707053485981171712