Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence?
Helicobacter pylori infects more than half the human population. However, the prevalence in Indonesia is low, as is the prevalence of gastric cancer. Hence, it could be instructive to compare these prevalence rates and their determining factors with those of countries that have high gastric cancer i...
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id-langga.1085242021-07-12T03:28:09Z http://repository.unair.ac.id/108524/ Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence? Muhammad Miftahussurur Langgeng Agung Waskito Kartika Afrida Fauzia Isna Mahmudah Dalla Doohan I Ketut Adnyana Ali Khomsan Neneng Ratnasari Yudith Annisa Ayu Rezkitha R Medicine (General) RC Internal medicine Helicobacter pylori infects more than half the human population. However, the prevalence in Indonesia is low, as is the prevalence of gastric cancer. Hence, it could be instructive to compare these prevalence rates and their determining factors with those of countries that have high gastric cancer incidence. Ethnicity and genetic characteristics of H. pylori are important determinants of the H. pylori infection rate in Indonesia. The infection rate is higher in Bataknese, Papuans and Buginese than in Javanese, the predominant ethnic group. Ethnicity is also an important determinant of the genetic characteristics of H. pylori. Analysis of CagA in the EPIYA segment showed that the predominant genotypes in Papuans, Bataknese and Buginese are ABB-, ABD- and ABC-type CagA, respectively. Meanwhile, in the countries with high gastric cancer incidence, almost all strains had East Asian type CagA. An antibiotic susceptibility evaluation showed that the standard triple therapy can still be used with caution in several cities. There is a very high rate of resistance to second-line regimens such as levofloxacin and metronidazole. Recent studies have shown that furazolidone, rifabutin and sitafloxacin are potential alternative treatments for antibiotic-resistant H. pylori infection in Indonesia. Rather than focusing on early detection and eradication as in countries with high gastric cancer prevalence, countries with low gastric cancer prevalence should focus on screening the several groups that have a high risk of gastric cancer. Editorial Office of Gut and Liver 2020 Article PeerReviewed text en http://repository.unair.ac.id/108524/1/6.%20Overview%20of%20Helicobacter%20pylori%20Infection%20in%20Indonesia%20What%20Distinguishes%20it%20from%20Countries%20with%20High%20Gastric%20Cancer%20Incidence.pdf text en http://repository.unair.ac.id/108524/2/6.pdf text en http://repository.unair.ac.id/108524/3/6.%20Overview%20of%20Helicobacter%20pylori%20Infection%20in%20Indonesia%20What%20Distinguishes%20it%20from%20Countries%20with%20High%20Gastric%20Cancer%20Incidence.pdf text en http://repository.unair.ac.id/108524/4/6.%20BUKTI%20KORESPONDENSI%20JURNAL%20overview%20gut%20liver.pdf Muhammad Miftahussurur and Langgeng Agung Waskito and Kartika Afrida Fauzia and Isna Mahmudah and Dalla Doohan and I Ketut Adnyana and Ali Khomsan and Neneng Ratnasari and Yudith Annisa Ayu Rezkitha (2020) Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence? Gut and Liver. pp. 1-12. ISSN 1976-2283 eISSN 2005-1212 https://www.gutnliver.org/journal/view.html?doi=10.5009/gnl20019 https://doi.org/10.5009/gnl20019 |
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R Medicine (General) RC Internal medicine Muhammad Miftahussurur Langgeng Agung Waskito Kartika Afrida Fauzia Isna Mahmudah Dalla Doohan I Ketut Adnyana Ali Khomsan Neneng Ratnasari Yudith Annisa Ayu Rezkitha Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence? |
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Helicobacter pylori infects more than half the human population. However, the prevalence in Indonesia is low, as is the prevalence of gastric cancer. Hence, it could be instructive to compare these prevalence rates and their determining factors with those of countries that have high gastric cancer incidence. Ethnicity and genetic characteristics of H. pylori are important determinants of the H. pylori infection rate in Indonesia. The infection rate is higher in Bataknese, Papuans and Buginese than in Javanese, the predominant ethnic group. Ethnicity is also an important determinant of the genetic characteristics of H. pylori. Analysis of CagA in the EPIYA segment showed that the predominant genotypes in Papuans, Bataknese and Buginese are ABB-, ABD- and ABC-type CagA, respectively. Meanwhile, in the countries with high gastric cancer incidence, almost all strains had East Asian type CagA. An antibiotic susceptibility evaluation showed that the standard triple therapy can still be used with caution in several cities. There is a very high rate of resistance to second-line regimens such as levofloxacin and metronidazole. Recent studies have shown that furazolidone, rifabutin and sitafloxacin are potential alternative treatments for antibiotic-resistant H. pylori infection in Indonesia. Rather than focusing on early detection and eradication as in countries with high gastric cancer prevalence, countries with low gastric cancer prevalence should focus on screening the several groups that have a high risk of gastric cancer. |
format |
Article PeerReviewed |
author |
Muhammad Miftahussurur Langgeng Agung Waskito Kartika Afrida Fauzia Isna Mahmudah Dalla Doohan I Ketut Adnyana Ali Khomsan Neneng Ratnasari Yudith Annisa Ayu Rezkitha |
author_facet |
Muhammad Miftahussurur Langgeng Agung Waskito Kartika Afrida Fauzia Isna Mahmudah Dalla Doohan I Ketut Adnyana Ali Khomsan Neneng Ratnasari Yudith Annisa Ayu Rezkitha |
author_sort |
Muhammad Miftahussurur |
title |
Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence? |
title_short |
Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence? |
title_full |
Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence? |
title_fullStr |
Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence? |
title_full_unstemmed |
Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence? |
title_sort |
overview of helicobacter pylori infection in indonesia: what distinguishes it from countries with high gastric cancer incidence? |
publisher |
Editorial Office of Gut and Liver |
publishDate |
2020 |
url |
http://repository.unair.ac.id/108524/1/6.%20Overview%20of%20Helicobacter%20pylori%20Infection%20in%20Indonesia%20What%20Distinguishes%20it%20from%20Countries%20with%20High%20Gastric%20Cancer%20Incidence.pdf http://repository.unair.ac.id/108524/2/6.pdf http://repository.unair.ac.id/108524/3/6.%20Overview%20of%20Helicobacter%20pylori%20Infection%20in%20Indonesia%20What%20Distinguishes%20it%20from%20Countries%20with%20High%20Gastric%20Cancer%20Incidence.pdf http://repository.unair.ac.id/108524/4/6.%20BUKTI%20KORESPONDENSI%20JURNAL%20overview%20gut%20liver.pdf http://repository.unair.ac.id/108524/ https://www.gutnliver.org/journal/view.html?doi=10.5009/gnl20019 https://doi.org/10.5009/gnl20019 |
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1707053490929401856 |