The Difference of Brain Derivat Neutrophic Factor of Mus Musculus Newborn from Adolescent and Adult Pregnancy

• Main Authors: Sri Wahyuni, Widjiati, Muhammad Miftahussurur
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Institute of Medico-Legal Publishers 2020
• Subjects: R Medicine (General); RC Internal medicine
• Online Access: http://repository.unair.ac.id/108644/1/35.%20The%20Difference%20of%20Brain%20Derivat%20Neutrophic%20Factor%20of%20Mus%20Musculus%20Newborn%20from%20Adolescent%20and%20Adult%20Pregnancy.pdf; http://repository.unair.ac.id/108644/2/35.%20The%20Difference%20of%20Brain%20Derivat%20Neutrophic%20Factor%20of%20Mus%20Musculus%20Newborn%20from%20Adolescent%20and%20Adult%20Pregnancy.pdf; http://repository.unair.ac.id/108644/3/35.%20The%20Difference%20of%20Brain%20Derivat%20Neutrophic%20Factor%20of%20Mus%20Musculus%20Newborn%20from%20Adolescent%20and%20Adult%20Pregnancy.pdf; http://repository.unair.ac.id/108644/; http://medicopublication.com/index.php/ijphrd/article/view/1680; https://doi.org/10.37506/ijphrd.v11i3.1680
• Institution: Universitas Airlangga

Background: The brain is the main organ involved in stress adaptation, while being the target of stress. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis and the system is adrenomedular Simpato thereby increasing the production of corticotropin-releasing hormone (CRH) and arginine-vasopressin (AVP) resulting in lower levels of Brain Derived Neurotrophic Factor (BDNF) in the hippocampus. Objective: The study aims to find out the difference of BDNFof Mus musculus newborn brain fromadolescents and adults pregnancy. Method: The samples on this study were 32 mice that divided by 2 groups were adolescent pregnancy mice group and adult pregnancy mice group. Mus musculus newborn were born by sectio and selected three with the heaviest, medium and lightest of each mothers to sacrificed their brains did decapitated and made immunohypochemical preparations and continued examination of the Immunoreactive Score to calculate Brain Derived Neurotrophic Factor expression. Result: BDNF expression of adolescent pregnancy mice group had higher (5.65±1.044) than adult pregnancy mice group (4.15±1,049). Test results showed that there was differences of BDNF expression in the brain p = 0,000 (p< 0.05) with details, there were differences in the cerebrum p = 0,015 and the cerebellum p = 0,000 between adolescent pregnancy mice group and adult pregnancy mice group. Conclusion: BDNF expression in brain of Mus musculus newborn from adolescent pregnancy lower than Mus musculus newborn from adult pregnancy.