In silico approach: biological prediction of nordentatin derivatives as anticancer agent inhibitors in the cAMP pathway

• Main Authors: Muhammad Ikhlas Abdjan, .-, Tin Myo Thant, .-, Nanik Siti Aminah*, .-, Alfinda Novi Kristanti, .-, Imam Siswanto, .-, Yoshiaki Takaya, .-
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Royal Society of Chemistry 2020
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://repository.unair.ac.id/109926/1/C01.%20Fulltext_IN%20SILICO_RSC%20ADVANCE%202020.pdf; http://repository.unair.ac.id/109926/2/C01.%20Review%20dan%20Validasi_IN%20SILICO_RSC%20ADVANCE%202020.pdf; http://repository.unair.ac.id/109926/3/C01_Similarity_In%20silico%20approach_.pdf; http://repository.unair.ac.id/109926/4/C01.%20Bukti%20komunikasi_In%20Silico%20aproach_RSC_2020-58-76.pdf; http://repository.unair.ac.id/109926/; https://pubs.rsc.org/en/content/articlelanding/2020/RA/D0RA07838G; https://doi.org/10.1039/D0RA07838G
• Institution: Universitas Airlangga

A combination of computational techniques has been carried out to predict the binding of nordentatin derivatives based on pyranocoumarin semi-synthesis with the target protein from the expression of the PDE4B gene. The inhibition of the cAMP pathway is the main target of anti-cancer drugs, which is...