Hypolipidemic Effects of Rosa Damascena Mill. Extract in Streptozotocin-induced Diabetic Rats

• Main Authors: Tamam Jauhar, -, Bilqis Inayatillah, -, Maftuchah Rochmanti, -, Achmad Basori, -
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Institute of Medico-Legal Publishers 2021
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology
• Online Access: https://repository.unair.ac.id/111375/1/Hypolipidemic%20Effects%20of%20Rosa%20Damascena%20Mill.%20Extract%20in%20Streptozotocin-induced%20Diabetic%20Rats.pdf; https://repository.unair.ac.id/111375/2/Hypolipidemic%20Effects.pdf; https://repository.unair.ac.id/111375/3/8.%20Acceptance%20Letter_Maftuchah%20with%20Tamam%20Jauhar_IJFMT.pdf; https://repository.unair.ac.id/111375/4/Hypolipidemic%20Effects%20of%20Rosa%20Damascena%20Mill.%20Extract%20in%20Streptozotocin-induced%20Diabetic%20Rats.pdf; https://repository.unair.ac.id/111375/; https://medicopublication.com/index.php/ijfmt/article/view/14461; https://doi.org/10.37506/ijfmt.v15i2.14461
• Institution: Universitas Airlangga

Background: Diabetes mellitus is a chronic hyperglycemic condition with a lot of complication which can lead to death. Vascular complication in diabetes commonly caused by dyslipidemia which characterized by decreased HDL, elevated LDL, Cholesterol and Triglyceride. Rosa damascena- an ornamental plantthoughts to have anti hyperglycemia and antioxidant effects because of its large amount of polyphenolic components . This study analyzed hypolipidemic activity properties of an ethanol extract of Rosa damascena by measuring the lipid profile using various doses. Methods: This research is experimental study with randomized post-test only control group design. Twenty male Wistar rats divided into 5 groups; The groups were Healthy Control Group (HCG), Diabetes Group (DG), and Extract Group: P1 (250 mg/kgBW), P2 (500 mg/kgBW), P3 (1000 mg/kgBW). All treatment groups were injected by single-dose streptozotocin 50 mg/kgBW to induce diabetes, and given the Rosa damascena ethanolic extract oral treatment for 2 weeks. Statistical results showed that Rosa damascena significantly decrease cholesterol (58.2±15.19), LDL (11±2.44) optimally in dose 250 mg/KgBW and triglyceride (96.7±44.2) optimally in dose 500 mg/kgBW after 14 days. Conclusion: Rosa damascena extract seems to be great candidate for anti-hyperlipidemic drugs.