Metformin Exerts Antifibrosis Effect on Human Lens Epithelial Cells Through Transforming Growth Factor-β Inhibition

• Main Authors: Dyah Purwita Trianggadewi, -, Indri Wahyuni, -, Deya Karsari, -, Maftuchah Rochmanti, -, Nurwasis, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: DR. P. R. YADAV 2019
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology
• Online Access: https://repository.unair.ac.id/111378/1/Metformin%20Exerts%20Antifibrosis%20Effect%20on%20Human%20Lens%20Epithelial%20Cells%20Through%20Transforming%20Growth%20Factor-Beta%20Inhibition.pdf; https://repository.unair.ac.id/111378/2/Metformin%20Exerts%20antiifibrosis.pdf; https://repository.unair.ac.id/111378/3/Metformin%20Exerts%20Antifibrosis%20Effect%20on%20Human%20Lens%20Epithelial%20Cells%20Through%20Transforming%20Growth%20Factor-Beta%20Inhibition.pdf; https://repository.unair.ac.id/111378/; http://www.connectjournals.com/achivestoc2.php?fulltext=3069400H_4911-4915.pdf&&bookmark=CJ-033216&&issue_id=Supp-02&&yaer=2019
• Institution: Universitas Airlangga

ABSTRACT : To investigate the antifibrosis effect of metformin human lens epithelial cells (HLECs) in vitro. HLECs were isolated from single donor of anterior capsule and treated with culture media supplemented with various doses of metformin as 0.1mM, 0.5 mM and 1mM. While the media was treated wit...