Associations between P53, Transforming Growth Factor Beta-1, and Interleukin-10 Serum Levels with Advanced Liver Disease and Hepatitis B Virus Infection

• Main Authors: Citrawati Dyah Kencono Wungu, -, Mochamad Amin, -, Ulfa Kholili, -, Gwenny Ichsan Prabowo, -, Poernomo Boedi Setiawan, -, Soetjipto, -, Retno Handajani, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Indian Journal of Forensic Medicine and Toxicology 2021
• Subjects: R Medicine (General); RA Public aspects of medicine
• Online Access: https://repository.unair.ac.id/112316/1/Association%20between%20P53%2C%20Transforming%20Growth%20Factor%20Beta-1%2C%20and%20Interleukin-10%20Serum%20Levels%20with%20Advanced%20Liver%20Disease%20and%20Hepatitis%20B%20Virus%20Infection.pdf; https://repository.unair.ac.id/112316/3/Association%20between%20P53%2C%20Transforming%20Growth%20Factor%20Beta-1%2C%20and%20Interleukin-10%20Serum%20Levels%20with%20Advanced%20Liver%20Disease%20and%20Hepatitis%20B%20Virus%20Infection.pdf; https://repository.unair.ac.id/112316/6/C2-Peer%20Review.pdf; https://repository.unair.ac.id/112316/; https://medicopublication.com/index.php/ijfmt/article/view/15736; https://doi.org/10.37506/ijfmt.v15i3.15736
• Institution: Universitas Airlangga

Background. Hepatitis B infection can lead to advanced liver disease (ALD) which causes serious health problems. Several factors that are thought to play a role in advanced liver disease are P53, Transforming Growth Factor-β1 (TGF-β1), and Interleukin-10 (IL-10). Therefore, this study aimed to determine the association between P53, TGF-β1, and IL-10 serum levels with ALD.Methods. We collected 68 sera from patients with HBV infection. P53, TGF-β1, and IL-10 serum levels were measured by ELISA. We also detected SNPs from P53 and TGF-b1 genes to determines their associations.Results and Conclusions: In this study, we obtained 41.18% CH patients and 58.82% ALD patients. Male patients outnumbered female in all groups. There was a significant relationship between serum P53 and TGF-b1 levels with ALD (p = 0.03 and 0.01, respectively), but not serum IL-10 levels. However, there was no significant relationship between SNP gene P53 and serum P53 levels nor between SNP gene TGF-b1 and serum TGF-b1 levels (p = 0.73 and 0.23, respectively).Both P53 and TGF-b1 serum leveles can act as biomarkers of prognosis and target therapy for ALD patients.