Uji Aktivitas Analgesik Campuran Ekstrak Kencur (Kaempferia Galanga) Dengan Kondroitin Dan Glukosamin Secara In Vivo Pada Mencit Putih (Mus Musculus)

• Main Author: Salsabila Aprilia Rizqi, '-
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian; Indonesian
• Published: 2021
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: https://repository.unair.ac.id/112378/1/1.%20JUDUL.pdf; https://repository.unair.ac.id/112378/2/2.%20ABSTRACT.pdf; https://repository.unair.ac.id/112378/3/3.%20DAFTAR%20ISI.pdf; https://repository.unair.ac.id/112378/4/4.%20BAB%20I%20PENDAHULUAN.pdf; https://repository.unair.ac.id/112378/5/5.%20BAB%20II%20TINJAUAN%20PUSTAKA.pdf; https://repository.unair.ac.id/112378/6/6.%20BAB%20III%20KERANGKA%20KONSEPTUAL.pdf; https://repository.unair.ac.id/112378/7/7.%20BAB%20IV%20METODE%20PENELITIAN.pdf; https://repository.unair.ac.id/112378/8/8.%20BAB%20V%20HASIL%20DAN%20PEMBAHASAN.pdf; https://repository.unair.ac.id/112378/9/9.%20BAB%20VI%20KESIMPULAN%20DAN%20SARAN.pdf; https://repository.unair.ac.id/112378/10/10.%20DAFTAR%20PUSTAKA.pdf; https://repository.unair.ac.id/112378/11/11%20LAMPIRAN.pdf; https://repository.unair.ac.id/112378/12/KESEDIAAN%20PUBLIKASI.pdf; https://repository.unair.ac.id/112378/; http://www.lib.unair.ac.id
• Institution: Universitas Airlangga

This study aims to determine the increase in analgesic activity of a mixture of 70 % ethanol extract of Kaempferia galanga rhizome with chondroitin and glucosamine in vivo. This study used writhing test as a method to determine its analgesic activity in mice (Mus musculus). Wriggling movements in mice were used as a parameter of the presence of pain. This study was an in vivo experimental study that uses sample of 28 healthy male Balb/c mice (Mus musculus). The sample was randomized into 7 groups. The first groups was given sodium CMC as negative control, the second groups was given aspirin 65 mg/kg BW as positive control, the third until fifth groups received a mixture of 70 % ethanol extract of Kaempferia galanga rhizome with chondroitin 52 mg/kg BW and glucosamine 65 mg/kg BW in the dose of 70 % ethanol extract of Kaempferia galanga rhizome respectively 840, 1.260 and 1.680 mg/kg BW, the sixth groups was given ethanol 70 % extract of Kaempferia galanga in dose 1.260 mg/kg BW and the seventh groups was given chondroitin 52 mg/kg BW and glucosamine 65 mg/kg BW. All interventions were administered by oral route. The result showed that the analgesic effect of a mixture of 70% ethanol extract of Kaempferia galanga rhizome with chondroitin and glucosamine was significantly different with negative control group (P<0,05) and the a mixture of 70 % ethanol extract of Kaempferia galanga rhizome in dose 1.680 mg/kg BW with chondroitin 52 mg/kg BW and glucosamine 65 mg/kg BW can increase analgesic activity in vivo as indicated by a significant difference in the frequency of stretching compared to aspirin at a dose of 65 mg/kgBW. From the result, it can be concluded that the administration of a mixture of 70 % ethanol extract of Kaempferia galanga rhizome at a dose of 1.260 and 1.680 mg/kg BW with glucosamine 65 mg/kgBW and chondroitin 52 mg/kgBW can increase the analgesic activity in vivo.