RENIN ANGIOTENSIN ALDOSTERONE SYSTEM (RAAS) PROFILE OF ADMINISTRATION OF ETHANOL EXTRACT OF PURPLE SWEET POTATO VAR. AYAMURASAKI IN DOCA-SALT HYPERTENSIVE RATS

• Main Authors: Irma Sarita Rahmawati, -, Soetjipto, -, Annis Catur Adi, -, Aulanni’am, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Dept. Food Technology, Faculty of Animal and Agricultural Sciences, Diponegoro University, Indonesia in collaboration with Indonesian Food Technologists. 2017
• Subjects: R Medicine
• Online Access: https://repository.unair.ac.id/113095/1/42.%20Renin%20angiotensin.pdf; https://repository.unair.ac.id/113095/2/42.%20Turnitin%20Renin%20Angiotensin.pdf; https://repository.unair.ac.id/113095/3/42%20Peer%20Renin%20Angiotensin.pdf; https://repository.unair.ac.id/113095/; https://appliedfoodtechnology.org/index.php/jaft/index; http://dx.doi.org/10.17728/jaft.46
• Institution: Universitas Airlangga

There is an increasing amount of evidence that oxidative stress related to hypertension can damage the function of diverse structures such as the aorta and kidney. It is a well-established fact that chlorogenic acid and anthocyanine found in purple sweet potato generates bioactive compound with antihypertensive and anti-ACE activities in RAA system. The present study sought to investigate anti-ACE activities in RAA system of extract ethanol of purple sweet potato (EP) in deoxycorticosterone acetate (DOCA–salt)–induced hypertensive rats (Rattus norvegicus). The rats were orally administrated a 95% ethanol extract of purple sweet potato (var. ayamurasaki) (EP) in a daily dose of 200 and 400 mg/kg body weight also chlorogenic acid (CA) of 700 mg/kg bw for 4 weeks. Activity of renin, ACE, and Ang II concentration were assessed. Inhibiting activity of renin, ACE, and decreasing Ang II concentration after treatment was observed in the DOCA-salt hypertensive rats compared to normotensive group rats; (P<0.05). This is the first report that demonstrates the lowering of blood pressure and anti-ACE in RAA-system effects of an ethanol extract of purple sweet potato, containing chlorogenic acid, in a DOCA–salt model of hypertension.