Glut-1 Is A Promising Target For Atp Deplesion On Diabetic Energy Deficiency Syndrome

• Main Authors: Bambang Purwanto, -, Harjanto, -, Elyana Asnar, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Faculty of Medicine, Universitas Airlangga, Indonesia 2017
• Subjects: R Medicine (General); RA Public aspects of medicine
• Online Access: https://repository.unair.ac.id/113592/1/21.%20Artikel.pdf; https://repository.unair.ac.id/113592/2/21.%20Similarity.pdf; https://repository.unair.ac.id/113592/3/peer%20review%2023.pdf; https://repository.unair.ac.id/113592/; https://e-journal.unair.ac.id/FMI/article/view/6443; http://dx.doi.org/10.20473/fmi.v53i3.6443
• Institution: Universitas Airlangga

Diabetes is a metabolic syndrome which characterized with insulin insensitivity, lack of GLUT-4 membrane presentation and ATP deficiency. ATP is needed for substrate phosphorylation, signalling pathways, protein translation and cellular survival. Since GLUT-1 was discovered as alternative glucose transporter on muscle membrane, some studies started to investigate it more. This study aimed to investigate GLUT-1 presentation on diabetes muscle membrane of rat model in time. Diabetes was obtained from a 50 mg/kg B.W of streptozotocin intra peritoneal injection on rat. We found that GLUT-1 presentation increased significantly in time of diabetic stages. It correlated negatively with GLUT-4 presentation and mortality. Eccentric downhill running on diabetic rat model improved GLUT-1 presentation and blood glucose level. It was promising for diabetes management therapy at the future.