INHIBITORY ACTIVITY OF COBALT(II)-MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2
Dengue virus (DENV) is a significant pathogen emerging worldwide as a cause of infectious disease. Antidengue treatments are urgently required to control the emergence of dengue. DENV is a mosquito-borne disease responsible for acute systemic diseases and serious health conditions. DENVs were distri...
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Lembaga Penyakit Tropis Universitas Airlangga
2017
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id-langga.1138022022-02-23T07:49:46Z https://repository.unair.ac.id/113802/ INHIBITORY ACTIVITY OF COBALT(II)-MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2 Teguh Hari Sucipto Siti Churrotin Harsasi Setyawati Kris Cahyo Mulyatno Ilham Harlan Amarullah Shuhai Ueda Tomohiro Kotaki Sri Sumarsih Puspa Wardhani Sri Subekti Bendryman Aryati Soegeng Soegijanto Masanori Kameoka R Medicine (General) RB37-56.5 Clinical pathology. Laboratory technique Dengue virus (DENV) is a significant pathogen emerging worldwide as a cause of infectious disease. Antidengue treatments are urgently required to control the emergence of dengue. DENV is a mosquito-borne disease responsible for acute systemic diseases and serious health conditions. DENVs were distributed in the tropical and sub-tropical areas and transmitted to humans by Aedes agypty and Aedes albopictus. Dengue vaccine or antiviral has not yet been clinically approved for humans, even though there have been great efforts toward this end. Antiviral activity against DENV is an important alternative for the characterization and development of drugs. Metal–organic compounds were reported to exhibit fungicidal, bactericidal, and antiviral activities its inhibitory activity was not significant, at high concentration it was more toxic to replicating cells than to stationary cell monolayers of Vero cells. The aim of this study is to investigate the antiviral effects of Cobalt(II)–Morin complex. This compound was further investigated for its inhibitory effect on the replication of DENV-2 in Vero cells. The replication of DENV was measured by enzyme-linked immunosorbent assay and the value of selectivity index (SI). SI was determined as the ratio of the 50% cytotoxic concentration (CC50) to the 50% inhibitory concentration (IC50). The IC50 value of the Cobalt(II)–Morin complex for DENV-2 was 3.08 µg/ml, and the CC50 value of the complex for Vero cells was 3.36 µg/ml; thus, the SI value was 1.09. The results of this study demonstrate the antidengue serotype 2 inhibitory activity of Cobalt(II)–Morin complex and its high toxicity in Vero cells. Further studies are not required before Co(II)–Morin can be applied in the treatment of DENV-2 infections. Lembaga Penyakit Tropis Universitas Airlangga 2017-12 Article PeerReviewed text en https://repository.unair.ac.id/113802/1/22%20Similarity.pdf text en https://repository.unair.ac.id/113802/2/22%20Artikel.pdf text en https://repository.unair.ac.id/113802/3/22.pdf Teguh Hari Sucipto and Siti Churrotin and Harsasi Setyawati and Kris Cahyo Mulyatno and Ilham Harlan Amarullah and Shuhai Ueda and Tomohiro Kotaki and Sri Sumarsih and Puspa Wardhani and Sri Subekti Bendryman and Aryati and Soegeng Soegijanto and Masanori Kameoka (2017) INHIBITORY ACTIVITY OF COBALT(II)-MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2. Indonesian Journal of Tropical and Infectious Disease, 6 (6). pp. 141-144. ISSN 2356-0991 https://e-journal.unair.ac.id/IJTID/article/view/6126 http://dx.doi.org/10.20473/ijtid.v6i6.6126 |
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R Medicine (General) RB37-56.5 Clinical pathology. Laboratory technique Teguh Hari Sucipto Siti Churrotin Harsasi Setyawati Kris Cahyo Mulyatno Ilham Harlan Amarullah Shuhai Ueda Tomohiro Kotaki Sri Sumarsih Puspa Wardhani Sri Subekti Bendryman Aryati Soegeng Soegijanto Masanori Kameoka INHIBITORY ACTIVITY OF COBALT(II)-MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2 |
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Dengue virus (DENV) is a significant pathogen emerging worldwide as a cause of infectious disease. Antidengue treatments are urgently required to control the emergence of dengue. DENV is a mosquito-borne disease responsible for acute systemic diseases and serious health conditions. DENVs were distributed in the tropical and sub-tropical areas and transmitted to humans by Aedes agypty and Aedes albopictus. Dengue vaccine or antiviral has not yet been clinically approved for humans, even though there have been great efforts toward this end. Antiviral activity against DENV is an important alternative for the characterization and development of drugs. Metal–organic compounds were reported to exhibit fungicidal, bactericidal, and antiviral activities its inhibitory activity was not significant, at high concentration it was more toxic to replicating cells than to stationary cell monolayers of Vero cells. The aim of this study is to investigate the antiviral effects of Cobalt(II)–Morin complex. This compound was further investigated for its inhibitory effect on the replication of DENV-2 in Vero cells. The replication of DENV was measured by enzyme-linked immunosorbent assay and the value of selectivity index (SI). SI was determined as the ratio of the 50% cytotoxic concentration (CC50) to the 50% inhibitory concentration (IC50). The IC50 value of the Cobalt(II)–Morin complex for DENV-2 was 3.08 µg/ml, and the CC50 value of the complex for Vero cells was 3.36 µg/ml; thus, the SI value was 1.09. The results of this study demonstrate the antidengue serotype 2 inhibitory activity of Cobalt(II)–Morin complex and its high toxicity in Vero cells. Further studies are not required before Co(II)–Morin can be applied in the treatment of DENV-2 infections. |
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Article PeerReviewed |
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Teguh Hari Sucipto Siti Churrotin Harsasi Setyawati Kris Cahyo Mulyatno Ilham Harlan Amarullah Shuhai Ueda Tomohiro Kotaki Sri Sumarsih Puspa Wardhani Sri Subekti Bendryman Aryati Soegeng Soegijanto Masanori Kameoka |
author_facet |
Teguh Hari Sucipto Siti Churrotin Harsasi Setyawati Kris Cahyo Mulyatno Ilham Harlan Amarullah Shuhai Ueda Tomohiro Kotaki Sri Sumarsih Puspa Wardhani Sri Subekti Bendryman Aryati Soegeng Soegijanto Masanori Kameoka |
author_sort |
Teguh Hari Sucipto |
title |
INHIBITORY ACTIVITY OF COBALT(II)-MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2 |
title_short |
INHIBITORY ACTIVITY OF COBALT(II)-MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2 |
title_full |
INHIBITORY ACTIVITY OF COBALT(II)-MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2 |
title_fullStr |
INHIBITORY ACTIVITY OF COBALT(II)-MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2 |
title_full_unstemmed |
INHIBITORY ACTIVITY OF COBALT(II)-MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2 |
title_sort |
inhibitory activity of cobalt(ii)-morin complex against the replication of dengue virus type 2 |
publisher |
Lembaga Penyakit Tropis Universitas Airlangga |
publishDate |
2017 |
url |
https://repository.unair.ac.id/113802/1/22%20Similarity.pdf https://repository.unair.ac.id/113802/2/22%20Artikel.pdf https://repository.unair.ac.id/113802/3/22.pdf https://repository.unair.ac.id/113802/ https://e-journal.unair.ac.id/IJTID/article/view/6126 http://dx.doi.org/10.20473/ijtid.v6i6.6126 |
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