An optimal control strategy to reduce the spread of malaria resistance
This paper presents a mathematical model of malaria transmission considering the resistance of malaria parasites to the anti-malarial drugs. The model also incorporates mass treatment and insecticide as control strategies. We consider the sensitive and resistant strains of malaria parasites in human...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article PeerReviewed |
| Language: | English English English English |
| Published: |
© 2015 Elsevier Inc.
2015
|
| Subjects: | |
| Online Access: | https://repository.unair.ac.id/114274/1/C10.%20Fulltext.pdf https://repository.unair.ac.id/114274/2/C10.%20Reviewer%20dan%20validasi.pdf https://repository.unair.ac.id/114274/3/C10.%20Similarity.pdf https://repository.unair.ac.id/114274/4/C10.%20Submission.pdf https://repository.unair.ac.id/114274/ https://www.sciencedirect.com/science/article/pii/S0025556415000073?via%3Dihub |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universitas Airlangga |
| Language: | English English English English |
| Summary: | This paper presents a mathematical model of malaria transmission considering the resistance of malaria parasites to the anti-malarial drugs. The model also incorporates mass treatment and insecticide as control strategies. We consider the sensitive and resistant strains of malaria parasites in human and mosquito populations. First, we investigated the existence and stability of equilibria of the model without control based on two basic reproduction ratios corresponding to the strains. Then, the Pontryagins Maximum Principle is applied to derive the necessary conditions for optimal control. Simulation results show the effectiveness of the optimal control to reduce the number of infected hosts and vectors. |
|---|