Infection in Neonates and Infants: Epidemiology Aspects

• Main Authors: Risa Etika, -, Agus Harianto, -, Martono Tri Utomo, -, Dina Angelika, -, Kartika Darma Handayani, -, Mahendra Tri Arif Sampurna, -
• Format: Book Section PeerReviewed
• Language: English; English; English
• Published: Ikatan Dokter Anak Indonesia - IDAI 2014
• Subjects: R Medicine (General); RJ Pediatrics
• Online Access: https://repository.unair.ac.id/116294/1/C42-Peer%20Review.pdf; https://repository.unair.ac.id/116294/2/C42-Artikel.pdf; https://repository.unair.ac.id/116294/3/FORM%20KARIL%2042.pdf; https://repository.unair.ac.id/116294/
• Institution: Universitas Airlangga

Neonatal infection is a one of the major cause of death and morbidity, especially in the first week of their life. So it is important to know about epidemiology aspects of neonatal infection and prevent neonatal sepsis by early diagnosis of Early Onset Sepsis (EOS) and managed this condition, as the first golden hours in neonatal infection. The challenges for clinicians are three fold: (1) identifiying neonates with a high likelihood of sepsis promptly and initiating antimicrobial therapy; (2) distinguishing "high risk" healthy-appearing infants of infants with clnical signs who do not require treatment; and (3) discontinuing antimicrobial therapy once sepsis is deemed unlikely. The optimal treatment of infants with suspected EOS is broad-spectrum antimicrobial agents (ampicillin and aminoglycoside). Once the pathogen is identified, antimicrobial therapy should be naarowed (unless synergism is needed). Antimicrobial therapy should be discontinued at 48 hours in clinical situations in which the probability of sepsis is low.