Chrobisiamone A, a new bischromone from Cassia siamea and a biomimetic transformation of 5-acetonyl-7-hydroxy-2-methylchromone into cassiarin A

• Main Authors: Shiori Oshimi, -, Yuichiro Tomizawa, -, Yusuke Hirasawa, -, Toshio Honda, -, Wiwied Ekasari, -, Aty Widyawaruyanti, -, Marcellino Rudyanto, -, Gunawan Indrayanto, -, Noor Cholies Zaini, -, Hiroshi Morita, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Elsevier 2008
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/116531/2/C-10_artikel.pdf; https://repository.unair.ac.id/116531/1/C-10_peer-review.pdf; https://repository.unair.ac.id/116531/3/C-10_similarity.pdf; https://repository.unair.ac.id/116531/; https://www.sciencedirect.com/science/article/abs/pii/S0960894X08005398?via%3Dihub; https://doi.org/10.1016/j.bmcl.2008.05.041
• Institution: Universitas Airlangga

A new bischromone, chrobisiamone A (1) with an antiplasmodial activity has been isolated from the leaves of Cassia siamea and the structure was elucidated by 2D NMR analysis. Cyclization of 5-acetonyl-7-hydroxy-2-methylchromone (2) in the presence of ammonium acetate resulted in generation of cassia...