Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida

• Main Authors: Yosuke Matsuno, -, Jun Deguchi, -, Yusuke Hirasawa, -, Kunio Ohyama, -, Hiroo Toyoda, -, Chieko Hirobe, -, Wiwied Ekasari, -, Aty Widyawaruyanti, -, Noor Cholies Zaini, -, Hiroshi Morita, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Elsevier 2008
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/116537/1/C-10_artikel.pdf; https://repository.unair.ac.id/116537/2/C-10_peer%20review.pdf; https://repository.unair.ac.id/116537/3/C-10_similarity.pdf; https://repository.unair.ac.id/116537/; https://www.sciencedirect.com/science/article/abs/pii/S0960894X08005313; https://doi.org/10.1016/j.bmcl.2008.05.035
• Institution: Universitas Airlangga

Two new cassane-type diterpenes, sucutiniranes A (1) and B (2), have been isolated from the seeds of Bowdichia nitida together with 6α-acetoxyvouacapane (3) and 6α,7β-diacetoxyvouacapane (4), and the structures of 1 and 2 were elucidated by using 2D NMR data and chemical correlations. Sucutinirane A (1) and 3 showed a moderate cytotoxicity against human colon carcinoma COLO201 cells, and 6α,7β-diacetoxyvouacapane (4) showed in vitro antiplasmodial activity against parasite Plasmodium falciparum 3D7.