The correlation of nutritional status with hematology toxicity of adjuvant chemotherapy in ovarian cancer

• Main Authors: Kadek Dharma Widhiarta, -, Brahmana Askandar, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Departemen Obstetri dan Ginekologi Fakultas Kedokteran Universitas Airlangga Surabaya 2021
• Subjects: R Medicine (General); RG Gynecology and obstetrics
• Online Access: https://repository.unair.ac.id/116656/1/Artikel%20C9.pdf; https://repository.unair.ac.id/116656/2/Peer%20Review%209.pdf; https://repository.unair.ac.id/116656/3/Similarity%209.pdf; https://repository.unair.ac.id/116656/; https://e-journal.unair.ac.id/MOG/article/view/21222; https://doi.org/10.20473/mog.V29I22021.57-62
• Institution: Universitas Airlangga

Objectives: To observe correlation of nutritional status using Nutritional Risk Index with the side effects of adjunctive haematological chemotherapy. Materials and Methods: This study was a retrospective cohort study observing whether or not hematologic side effects occurred during chemotherapy based on medical records of postoperative ovarian cancer patients receiving adjuvant chemotherapy. Results: Sixty-eight subjects with age range of 31-50 years (44.1%) multipara (68.8%), and advanced stage (52.1%) were observed. An increase was found in the diagnosis of malnutrition between the IMT method and NRI, which was 18.7% compared to 43.7%. A significant correlation was found between preoperative malnutrition and the incidence of anaemia after adjuvant chemotherapy for ovarian cancer patients (p=0.002). Whereas, in the event of leukopenia and thrombocytopenia, there were no significant correlations with p=0.675 and p=0.415, respectively. Conclusion: There was an increase in malnutrition rate with the use of NRI compared with BMI and there was a significant correlation between malnutrition and side effects of anaemia in patients with ovarian cancer who underwent surgery and continued with adjuvant chemotherapy.