Blockade of HIF-1α and STAT3 by hyaluronate-conjugated TAT- chitosan-SPION nanoparticles loaded with siRNA molecules prevents tumor growth

• Main Authors: Hendrik Setia Budi, -, Sepideh Izadi, -, Anton Timoshin, -, Sima Heydarzadeh Asl, -, Behzad Beyzai, -, Amir Ghaderpour, -, Fatemeh Alian, -, Farzaneh Sadat Eshaghi, -, Seyedeh Mahboubeh Mousavi, -, Behnam Rafiee, -, Afshin Nikkhoo, -, Armin Ahmadi, -, Hadi Hassannia, -, Majid Ahmadi, -, Mozhdeh Sojoodi, -, Farhad Jadidi-Niaragh, -
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Elsevier 2021
• Subjects: R Medicine; RK1-715 Dentistry
• Online Access: https://repository.unair.ac.id/116932/1/2.Blockade%20of%20HIF-1%CE%B1%20and%20STAT3%20by%20hyaluronate-conjugated%20TATchitosan-.pdf; https://repository.unair.ac.id/116932/2/Plagiasi%20artikel%20no%202.pdf; https://repository.unair.ac.id/116932/4/Bukti%20Korespondensi%20Artikel%20no.%202.pdf; https://repository.unair.ac.id/116932/8/2..pdf; https://repository.unair.ac.id/116932/; https://www.sciencedirect.com/science/article/pii/S1549963421000162?via%3Dihub; https://doi.org/10.1016/j.nano.2021.102373
• Institution: Universitas Airlangga

HIF-1α and STAT3 are two of the critical factors in the growth, proliferation, and metastasis of cancer cells and play a crucial role in inhibiting anti-cancer immune responses. Therefore, we used superparamagnetic iron oxide (SPION) nanoparticles (NPs) coated with thiolated chitosan (ChT) and tri...