The Potential of Red Dragon Fruit (Hylocereuspolyrhizus) Rind Extract Accelerates Wound Healing Process Post Tooth Extraction
Introduction: Biological process of wound healing in soft tissue injury which include some phase that its highly or¬ganized cascade, such as haemostasis, inflammation, proliferation and remodeling. Healing process will be impaired when there is an interference with one of the four of the phase not g...
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Malaysian Journal of Medicine and Health Sciences
2020
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id-langga.1169352023-04-20T04:43:51Z https://repository.unair.ac.id/116935/ The Potential of Red Dragon Fruit (Hylocereuspolyrhizus) Rind Extract Accelerates Wound Healing Process Post Tooth Extraction Hendrik Setia Budi, - Wisnu Setyari Juliastuti, - Rini Devijanti Ridwan, - Yuliati, - Rofillah Putri Andhini, - R Medicine RK1-715 Dentistry Introduction: Biological process of wound healing in soft tissue injury which include some phase that its highly or¬ganized cascade, such as haemostasis, inflammation, proliferation and remodeling. Healing process will be impaired when there is an interference with one of the four of the phase not going well. This study is aimed to proving the role of dragon fruit peel extract towards the interpretation of TGF- β, fibroblast cell and formation of new blood vessels during wound healing process. Methods: 20 rattus norwegicus wistar strain rats are separated into four groups. The one lower incisor is extracted, afterward the wound post extraction of the treatment group was treated with dragon fruit peel extract gel with the concentration of 15%, 30% and 60%, meanwhile, for the control groups, they are treat¬ed with polyethylene glycol gel. On the fourth day, the rats were sacrificed and preparation of immunohistochemi¬cal and histopathology are made. Observe under the light microscope with 400x magnification. Results: This study shows that the 30% concentration increase the expression of TGF- β (16.6±2.07), fibroblast proliferation (77.6±5.27) and new blood vessels (33.8±2.28) compare to the control group, 15% and 60% concentration in a meaningful way (p=0.00, p=0.00 and p=0.00). Conclusions: The dragon fruit peel extract gel may affect the wound healing process of extraction by increasing the expression of TGF- β, number of fibroblast and formation of new blood vessels Malaysian Journal of Medicine and Health Sciences 2020-07 Article PeerReviewed text en https://repository.unair.ac.id/116935/1/5.The%20Potential%20of%20Red%20Dragon%20Fruit%20%28Hylocereuspolyrhizus%29%20Rind%20Extract%20Accelerates%20Wound%20Healing%20Process%20Post%20Tooth%20Extraction.pdf text en https://repository.unair.ac.id/116935/2/Plagiasi%20artikel%20no%205.pdf text en https://repository.unair.ac.id/116935/4/Bukti%20Korespondensi%20Artikel%20no.%205.pdf text en https://repository.unair.ac.id/116935/8/5..pdf Hendrik Setia Budi, - and Wisnu Setyari Juliastuti, - and Rini Devijanti Ridwan, - and Yuliati, - and Rofillah Putri Andhini, - (2020) The Potential of Red Dragon Fruit (Hylocereuspolyrhizus) Rind Extract Accelerates Wound Healing Process Post Tooth Extraction. Malaysian Journal of Medicine and Health Sciences, - (-). pp. 37-41. ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020070611200608_MJMHS_0222.pdf - |
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Introduction: Biological process of wound healing in soft tissue injury which include some phase that its highly or¬ganized cascade, such as haemostasis, inflammation, proliferation and remodeling. Healing process will be impaired when there is an interference with one of the four of the phase not going well. This study is aimed to proving the role of dragon fruit peel extract towards the interpretation of TGF- β, fibroblast cell and formation of new blood vessels during wound healing process. Methods: 20 rattus norwegicus wistar strain rats are separated into four groups. The one lower incisor is extracted, afterward the wound post extraction of the treatment group was treated with dragon fruit peel extract gel with the concentration of 15%, 30% and 60%, meanwhile, for the control groups, they are treat¬ed with polyethylene glycol gel. On the fourth day, the rats were sacrificed and preparation of immunohistochemi¬cal and histopathology are made. Observe under the light microscope with 400x magnification. Results: This study shows that the 30% concentration increase the expression of TGF- β (16.6±2.07), fibroblast proliferation (77.6±5.27) and new blood vessels (33.8±2.28) compare to the control group, 15% and 60% concentration in a meaningful way (p=0.00, p=0.00 and p=0.00). Conclusions: The dragon fruit peel extract gel may affect the wound healing process of extraction by increasing the expression of TGF- β, number of fibroblast and formation of new blood vessels |
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Article PeerReviewed |
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Hendrik Setia Budi, - Wisnu Setyari Juliastuti, - Rini Devijanti Ridwan, - Yuliati, - Rofillah Putri Andhini, - |
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Hendrik Setia Budi, - Wisnu Setyari Juliastuti, - Rini Devijanti Ridwan, - Yuliati, - Rofillah Putri Andhini, - |
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Hendrik Setia Budi, - |
title |
The Potential of Red Dragon Fruit (Hylocereuspolyrhizus) Rind Extract Accelerates Wound Healing Process Post Tooth Extraction |
title_short |
The Potential of Red Dragon Fruit (Hylocereuspolyrhizus) Rind Extract Accelerates Wound Healing Process Post Tooth Extraction |
title_full |
The Potential of Red Dragon Fruit (Hylocereuspolyrhizus) Rind Extract Accelerates Wound Healing Process Post Tooth Extraction |
title_fullStr |
The Potential of Red Dragon Fruit (Hylocereuspolyrhizus) Rind Extract Accelerates Wound Healing Process Post Tooth Extraction |
title_full_unstemmed |
The Potential of Red Dragon Fruit (Hylocereuspolyrhizus) Rind Extract Accelerates Wound Healing Process Post Tooth Extraction |
title_sort |
potential of red dragon fruit (hylocereuspolyrhizus) rind extract accelerates wound healing process post tooth extraction |
publisher |
Malaysian Journal of Medicine and Health Sciences |
publishDate |
2020 |
url |
https://repository.unair.ac.id/116935/1/5.The%20Potential%20of%20Red%20Dragon%20Fruit%20%28Hylocereuspolyrhizus%29%20Rind%20Extract%20Accelerates%20Wound%20Healing%20Process%20Post%20Tooth%20Extraction.pdf https://repository.unair.ac.id/116935/2/Plagiasi%20artikel%20no%205.pdf https://repository.unair.ac.id/116935/4/Bukti%20Korespondensi%20Artikel%20no.%205.pdf https://repository.unair.ac.id/116935/8/5..pdf https://repository.unair.ac.id/116935/ https://medic.upm.edu.my/upload/dokumen/2020070611200608_MJMHS_0222.pdf |
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