THE CORRELATION BETWEEN PLASMA REACTIVE OXYGEN SPECIES AND HEARING THRESHOLD LEVELS IN PRESBYCUSIS PATIENTS
Background: Presbycusis is a hearing loss due to the degeneration process in elderly people of 65 years old and beyond, characterized by a decrease in hearing sensitivity in both ears. Reactive oxygen species (ROS) are assumed to have an important role in the pathogenesis of presbycusis. Purpose: To...
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id-langga.1175692023-05-12T02:13:49Z https://repository.unair.ac.id/117569/ THE CORRELATION BETWEEN PLASMA REACTIVE OXYGEN SPECIES AND HEARING THRESHOLD LEVELS IN PRESBYCUSIS PATIENTS Nyilo Purnami, - Anita Nuraini, - Bakti Surarso, - R Medicine (General) RF Otorhinolaryngology Background: Presbycusis is a hearing loss due to the degeneration process in elderly people of 65 years old and beyond, characterized by a decrease in hearing sensitivity in both ears. Reactive oxygen species (ROS) are assumed to have an important role in the pathogenesis of presbycusis. Purpose: To find out the correlation between ROS levels in plasma and hearing threshold levels in presbycusis patients. Method: The design was cross sectional and conducted at the Outpatient Clinic of Neurotology Division, Geriatric Clinic, Clinical Pathology Installation, and Central Installation of Biomaterials Network Bank of Dr. Soetomo Hospital. Samples were taken by consecutive sampling for audiometric examination and measurement of ROS levels in plasma. Results: Fifty samples were collected, ROS levels in plasma were found with mean (SD) of 2.46 ng/ml (0.84). The mean hearing threshold level was 47.70 dB (12.42). The Pearson statistical test revealed a significant correlation between ROS levels in plasma and hearing threshold levels, with p=0.003 (p<0.05), and the correlation coefficient (r) 0.41. Conclusion: There was a correlation between ROS in plasma and hearing threshold levels in presbycusis patients, with a significant moderate-positive correlation pattern. It indicated that the higher the ROS levels in plasma, the higher the hearing threshold levels in presbycusis patients. Perhati-KL Indonesia 2019 Article PeerReviewed text en https://repository.unair.ac.id/117569/1/Bukti%20Korespondensi%20C15.pdf text en https://repository.unair.ac.id/117569/2/Artikel%20C15.pdf text en https://repository.unair.ac.id/117569/3/24.pdf text en https://repository.unair.ac.id/117569/4/Similarity%20C15.pdf text id https://repository.unair.ac.id/117569/7/23.pdf text en https://repository.unair.ac.id/117569/9/9.%20Ethic%20-%20The%20Correlation%20between%20plasma%20reactive%20ROS.pdf text en https://repository.unair.ac.id/117569/10/9.%20The%20Correlation%20between%20plasma%20reactive%20ROS.pdf text en https://repository.unair.ac.id/117569/13/Ethic-%20The%20Correlation%20Between%20Plasma%20Reactive%20Oxygen%20species%20and%20Hearing.pdf Nyilo Purnami, - and Anita Nuraini, - and Bakti Surarso, - (2019) THE CORRELATION BETWEEN PLASMA REACTIVE OXYGEN SPECIES AND HEARING THRESHOLD LEVELS IN PRESBYCUSIS PATIENTS. Oto Rhino Laryngologica Indonesiana, 49 (1). pp. 19-28. ISSN 25983970 https://www.orli.or.id/index.php/orli/article/view/291 https://doi.org/10.32637/orli.v49i1.291 |
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R Medicine (General) RF Otorhinolaryngology |
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R Medicine (General) RF Otorhinolaryngology Nyilo Purnami, - Anita Nuraini, - Bakti Surarso, - THE CORRELATION BETWEEN PLASMA REACTIVE OXYGEN SPECIES AND HEARING THRESHOLD LEVELS IN PRESBYCUSIS PATIENTS |
description |
Background: Presbycusis is a hearing loss due to the degeneration process in elderly people of 65 years old and beyond, characterized by a decrease in hearing sensitivity in both ears. Reactive oxygen species (ROS) are assumed to have an important role in the pathogenesis of presbycusis. Purpose: To find out the correlation between ROS levels in plasma and hearing threshold levels in presbycusis patients. Method: The design was cross sectional and conducted at the Outpatient Clinic of Neurotology Division, Geriatric Clinic, Clinical Pathology Installation, and Central Installation of Biomaterials Network Bank of Dr. Soetomo Hospital. Samples were taken by consecutive sampling for audiometric examination and measurement of ROS levels in plasma. Results: Fifty samples were collected, ROS levels in plasma were found with mean (SD) of 2.46 ng/ml (0.84). The mean hearing threshold level was 47.70 dB (12.42). The Pearson statistical test revealed a significant correlation between ROS levels in plasma and hearing threshold levels, with p=0.003 (p<0.05), and the correlation coefficient (r) 0.41. Conclusion: There was a correlation between ROS in plasma and hearing threshold levels in presbycusis patients, with a significant moderate-positive correlation pattern. It indicated that the higher the ROS levels in plasma, the higher the hearing threshold levels in presbycusis patients. |
format |
Article PeerReviewed |
author |
Nyilo Purnami, - Anita Nuraini, - Bakti Surarso, - |
author_facet |
Nyilo Purnami, - Anita Nuraini, - Bakti Surarso, - |
author_sort |
Nyilo Purnami, - |
title |
THE CORRELATION BETWEEN PLASMA REACTIVE OXYGEN SPECIES AND HEARING THRESHOLD LEVELS IN PRESBYCUSIS PATIENTS |
title_short |
THE CORRELATION BETWEEN PLASMA REACTIVE OXYGEN SPECIES AND HEARING THRESHOLD LEVELS IN PRESBYCUSIS PATIENTS |
title_full |
THE CORRELATION BETWEEN PLASMA REACTIVE OXYGEN SPECIES AND HEARING THRESHOLD LEVELS IN PRESBYCUSIS PATIENTS |
title_fullStr |
THE CORRELATION BETWEEN PLASMA REACTIVE OXYGEN SPECIES AND HEARING THRESHOLD LEVELS IN PRESBYCUSIS PATIENTS |
title_full_unstemmed |
THE CORRELATION BETWEEN PLASMA REACTIVE OXYGEN SPECIES AND HEARING THRESHOLD LEVELS IN PRESBYCUSIS PATIENTS |
title_sort |
correlation between plasma reactive oxygen species and hearing threshold levels in presbycusis patients |
publisher |
Perhati-KL Indonesia |
publishDate |
2019 |
url |
https://repository.unair.ac.id/117569/1/Bukti%20Korespondensi%20C15.pdf https://repository.unair.ac.id/117569/2/Artikel%20C15.pdf https://repository.unair.ac.id/117569/3/24.pdf https://repository.unair.ac.id/117569/4/Similarity%20C15.pdf https://repository.unair.ac.id/117569/7/23.pdf https://repository.unair.ac.id/117569/9/9.%20Ethic%20-%20The%20Correlation%20between%20plasma%20reactive%20ROS.pdf https://repository.unair.ac.id/117569/10/9.%20The%20Correlation%20between%20plasma%20reactive%20ROS.pdf https://repository.unair.ac.id/117569/13/Ethic-%20The%20Correlation%20Between%20Plasma%20Reactive%20Oxygen%20species%20and%20Hearing.pdf https://repository.unair.ac.id/117569/ https://www.orli.or.id/index.php/orli/article/view/291 https://doi.org/10.32637/orli.v49i1.291 |
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1767194138249265152 |