Perbandingan Persentase Hasil Sintesis antara N-Benzilidenisonikotinohidrazida dengan N-(2-Metoksibenzjliden)Isonlkotinohidrazlda dari Isoniazida

• Main Author: Tavia Cesarin Prastari, 051111232
• Format: Theses and Dissertations NonPeerReviewed
• Language: English; English
• Published: 2015
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: https://repository.unair.ac.id/118294/2/ABSTRAK.pdf; https://repository.unair.ac.id/118294/1/KKB%20KK-2%20FF%20KF%2044_15%20Pra%20p.pdf; https://repository.unair.ac.id/118294/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

In this research, the author synthesized N-benzylideneisonicotinohydrazide and N -(2-methoxybenzylidene )isonicotinohydrazide. The obtained yield of products would be compared (with the same condition). Reaction mechanism of this synthesis is nucleophilic addition by eliminating water. Methoxy group at 2-methoxybenzaldehyde caused hindrance effect and made it is more difficult to be attacked by a nucleophile. The structure of the products were identified by UV spectrophotometry, IR spectrophotometry, and IH_NMR spectrometry. The N-benzylideneisonicotinohydrazide is produced as white crystal with 98.32% yield and N-(2-methoxybenzylidene)isonicotinohydrazide is produced as white crystal with 66.52% yield. As conclusion, synthesis of Nbenzylideneisonicotinohydrazide gave yield higher than N-(2-methoxybenzylidene )isonicotinohydrazide.