The prevalence, predictors and outcomes of acute liver injury among patients with COVID-19: A systematic review and meta-analysis

• Main Authors: Harapan, -, Jonny Karunia Fajar, -, Supriono, -, Gatot Soegiarto, -, Laksmi Wulandari, -, Fiha Seratin, -, Nyoman Gede Prayudi, -, Dara Puspita Dewi, -, Maria Theresia Monica Elsina, -, Lasarus Atamou, -, Sinta Wiranata, -, Dhito Pemi Aprianto, -, Erlin Friska, -, D Fitria Sari Firdaus, -, Makdum Alaidin, -, Firdha Aprillia Wardhani, -, Milda Husnah, -, Nurdina Wahyu Hidayati, -, Yeni Hendriyanti, -, Kristia Wardani, -, Arde Evatta, -, Reizal Audi Manugan, -, Wiryawan Pradipto, -, Ade Rahmawati, -, Fredo Tamara, -, Aditya Indra Mahendra, -, Firzan Nainu, -, Budi Santoso, -, Chandra Adi Irawan Primasatya, -, Nindy Tjionganata, -, Hendarto Arif Budiman, -
• Format: Article PeerReviewed
• Language: English; English; English; English; English
• Published: John Wiley and Sons Ltd 2021
• Subjects: R Medicine (General); RC Internal medicine
• Online Access: https://repository.unair.ac.id/118330/1/2.%20Korespondensi_Artikel%2019.pdf; https://repository.unair.ac.id/118330/2/Karil%20Artikel%2019.pdf; https://repository.unair.ac.id/118330/3/1.%20Full%20Text_%20Asrtikel%2019.pdf; https://repository.unair.ac.id/118330/4/3.%20Turnitin_Artikel%2019.pdf; https://repository.unair.ac.id/118330/8/1.Karil_16.pdf; https://repository.unair.ac.id/118330/; https://onlinelibrary.wiley.com/doi/10.1002/rmv.2304; https://doi.org/10.1002/rmv.2304
• Institution: Universitas Airlangga

The data on the predictors and prognosis of acute liver injury (ALI) among patients in coronavirus disease 2019 (COVID-19) patients are limited. The aim of this study was to determine the prevalence, predictors and outcomes of ALI among patients with COVID-19. A systematic review was conducted up to 10 June 2021. The relevant papers were searched from PubMed, Embase, Cochrane and Web of Science, and the data were analysed using a Z test. A total of 1331 papers were identified and 16 papers consisting of 1254 COVID-19 with ALI and 4999 COVID-19 without ALI were analysed. The cumulative prevalence of ALI among patients with COVID-19 was 22.8%. Male and having low lymphocyte levels were more likely to be associated with ALI compared with female and having higher lymphocyte level, odds ratio (OR): 2.70; 95% confidence interval (CI): 2.03, 3.60 and mean difference (MD) −125; 95% CI: −207, −43, respectively. COVID-19 patients with ALI had higher risk of developing severe COVID-19 compared with those without ALI (OR: 3.61; 95% CI: 2.60, 5.02). Our findings may serve as the additional evaluation for the management of ALI in COVID-19 patients.