Interferon-Gamma Profile of Mice (Mus musculus L.) after Complete SARS-CoV-2 Vaccination

• Main Authors: Balqis Afifah, -, Soeharsono, -, Imam Mustofa, -, Kuncoro Puguh Santoso, -, Jola Rahmahani, -, Arif Nur Muhammad Ansori, -, Reviany Vibrianita Nidom, -, Astria Novitasari Nidom, -, Muhammad Khaliim Jati Kusala, -, Dhani Prakoso, -, Nor Laela Ramadhaniyah, -
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Universidad Tecnica de Manabi 2022
• Subjects: SF405.5-407 Laboratory animals; SF910 Other diseases and conditions
• Online Access: https://repository.unair.ac.id/118375/7/Artikel_Jola_Rahmahani.pdf; https://repository.unair.ac.id/118375/3/Similarity_Jola_Rahmahani.pdf; https://repository.unair.ac.id/118375/9/Peer_Review_Jola_Rahmahani.pdf; https://repository.unair.ac.id/118375/11/Surat_Keterangan_Uji_Etical_Clearence.pdf; https://repository.unair.ac.id/118375/
• Institution: Universitas Airlangga

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (COVID-19) have afflicted millions of people in a worldwide pandemic. Several vaccines have been developed to prevent infection and illness. The success of preventing and controlling the COVID-19 by using an effective and efficient vaccine. This study aimed to find out the profile of interferon-gamma (IFN-γ) after COVID-19 vaccination. This study conducted at Animal Laboratory Professor Nidom Foundation (ABSL-3) from December 2021 to February 2022. The present study is an experimental study with a post test only control group design using 90 mice (Mus musculus L.). The test group consisted of mice injected subcutan with 0.1 mL PBS (P1), 0.1 mL adjuvant 1 (P2), 0.1 mL adjuvant 2 (P3), 0.1 mL VLPs SARS-CoV-2 10 μg (P4), 0.1 mL VLPs SARS-CoV-2 dose 50 μg (P5), 0.1 mL VLPs SARS-CoV-2 10 μg + adjuvant 1 (P6), 0.1 mL VLPs SARS-CoV-2 10 μg + adjuvant 2 (P7), 0.1 mL VLPs SARS-CoV-2 50 μg + adjuvant 1 (P8), and 0.1 mL VLPs SARS-CoV-2 50 μg + adjuvant 2 (P9). The data analysed by using ANOVA Keywords : COVID-19, virus-like particles, adjuvant, IFN-γ, IgG