Association of serum KL-6 levels on COVID-19 severity: A cross-sectional study design with purposive sampling

• Main Authors: Dhadhari Suryananda, Titah, Resti Yudhawati Meliana, ,-
• Format: Article PeerReviewed
• Language: English; English; Indonesian; English; Indonesian; English
• Published: Elsevier B.V
• Subjects: R Medicine (General); R5-920 Medicine (General)
• Online Access: https://repository.unair.ac.id/118460/3/KELENGKAPAN.pdf; https://repository.unair.ac.id/118460/4/turnitine.pdf; https://repository.unair.ac.id/118460/12/Association%20of%20serum%20KL-6%20levels%20on%20COVID-19%20severity%20A%20cross-sectional%20study%20design%20with%20purposive%20sampling.pdf; https://repository.unair.ac.id/118460/13/Association%20of%20serum%20KL-6%20levels%20on%20COVID-19_compressed.pdf; https://repository.unair.ac.id/118460/15/Karil%20Association%20of%20serum%20KL-6.pdf; https://repository.unair.ac.id/118460/17/8%20artikel.pdf; https://repository.unair.ac.id/118460/; https://www.sciencedirect.com/science/article/pii/S2049080121006233?via%3Dihub
• Institution: Universitas Airlangga

Background The main target of SARS-CoV2 is the alveolar type II (AT2) cells of the lung. SARS-CoV2 evades the innate immune system resulting in the release of proinflammatory cytokines (IL-1β, IL-6, TNF-α) which causes AT2 cell damage. Krebs von den Lungen (KL-6) is a specific biomarker of AT2 cell damage. KL-6 is produced in AT2 cells that are injured/regenerated. Objective Research that discusses the role of KL-6 in COVID-19 is still being debated and not much has been done in Indonesia. Methods This study was an analytical study with a prospective design on 75 COVID-19 patients who were treated. Subjects were divided into two large groups according to their degree of severity, 57 subjects with severe degrees and 18 subjects with non-severe degrees. The serum KL-6 levels were measured on days 0 and 6. Data were analyzed using paired t-test and independent t-test for data were normally distributed and Wilcoxon test and Mann Whitney test for data that were not normally distributed. Result In this study, the mean serum KL-6 for day 0 in the severe group was higher than the non-severe group with values of 45.70 U/mL and 44.85 U/mL. On day 6, the mean serum KL-6 in the severe group was lower than that in the non-severe group with values of 41.3 U/mL and 41.95 U/mL. Serum KL-6 in the severe group experienced an even greater decrease than the non-severe group. Conclusion There was no significant association between serum KL-6 values on 0 days in the severity of COVID-19.