Immunoregulatory Property of C-Type Lectin-Like Receptors in Fibrosing Interstitial Lung Diseases
The innate immune system identifies exogenous threats or endogenous stress through germline-encoded receptors called pattern recognition receptors (PRRs) that initiate consecutive downstream signaling pathways to control immune responses. However, the contribution of the immune system and inflammati...
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| Main Authors: | , , , |
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| Format: | Article PeerReviewed |
| Language: | English Indonesian English |
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MDPI Multidisciplinary Digital Publishing Institute
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| Online Access: | https://repository.unair.ac.id/118527/3/Turnitin_.pdf https://repository.unair.ac.id/118527/7/Karil%20Immunoregulatory%20Property.pdf https://repository.unair.ac.id/118527/9/Immunoregulatory%20Property%20of%20C-Type.pdf https://repository.unair.ac.id/118527/ https://www.mdpi.com/1422-0067/21/10/3665/htm https://doi.org/10.3390%2Fijms21103665 |
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| Institution: | Universitas Airlangga |
| Language: | English Indonesian English |
| Summary: | The innate immune system identifies exogenous threats or endogenous stress through germline-encoded receptors called pattern recognition receptors (PRRs) that initiate consecutive downstream signaling pathways to control immune responses. However, the contribution of the immune system and inflammation to fibrosing interstitial lung diseases (ILD) remains poorly understood. Immunoreceptor tyrosine-based motif-bearing C-type lectin-like receptors (CTLRs) may interact with various immune cells during tissue injury and wound repair processes. Dectin-1 is a CTLR with dominant mechanisms manifested through its intracellular signaling cascades, which regulate fibrosis-promoting properties through gene transcription and cytokine activation. Additionally, immune impairment in ILD facilitates microbiome colonization; hence, Dectin-1 is the master protector in host pulmonary defense against fungal invasion. Recent progress in determining the signaling pathways that control the balance of fibrosis has implicated immunoreceptor tyrosine-based motif-bearing CTLRs as being involved, either directly or indirectly, in the pathogenesis of fibrosing ILD.
Keywords: innate immunity, pattern recognition receptors, C-type lectin-like receptors, immunoregulatory receptor, tyrosine-based signaling motifs, interstitial lung diseases |
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