Effects of Pomegranate Extracts on MMP-1, TIMP-1, MMP-1/TIMP-1 Ratio, and Type I Collagen to Inhibit Right Ventricular Fibrosis in Animal Models

• Main Authors: Taufiq Hidayat, -, I Ketut Alit Utamayasa, -, Mahrus A. Rahman, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: North University of Baia Mare 2019
• Subjects: R Medicine (General); RJ Pediatrics
• Online Access: https://repository.unair.ac.id/118917/1/1.pdf; https://repository.unair.ac.id/118917/3/1.pdf; https://repository.unair.ac.id/118917/7/1.pdf; https://repository.unair.ac.id/118917/; http://chimie-biologie.ubm.ro/carpathian_journal/Papers_11(5)/CJFST11(5)2019_11.pdf; https://doi.org/10.34302/crpjfst/2019.11.5.11
• Institution: Universitas Airlangga

Pulmonary arterial hypertension (PAH) may cause myocardial fibrosis. The process involves collagenase, the metalloproteinase matrix (MMPs), and tissue inhibitors of metalloproteinase (TIMPs). The accumulation of type I collagen in the right ventricular heart muscle may result in right ventricular fi...