Perbandingan Persentase Hasil Sintesis Antara N-Benzilidenisonikotinohidrazida dengan N-(2-metoksibenzjliden)Isonikotinohidrazida dari Isoniazida
In this research, the author synthesized N-benzylideneisonicotinohydrazide and N -(2-methoxybenzylidene )isonicotinohydrazide. The obtained yield of products would be compared (with the same condition). Reaction mechanism of this synthesis is nucleophilic addition by eliminating water. Methoxy g...
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| Main Author: | |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | English English |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://repository.unair.ac.id/119010/1/KKB%20KK-2%20FF%20FK%2044_15%20Pra%20p_ABSTRAK.pdf https://repository.unair.ac.id/119010/2/KKB%20KK-2%20FF%20FK%2044_15%20Pra%20p.pdf https://repository.unair.ac.id/119010/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | English English |
| Summary: | In this research, the author synthesized N-benzylideneisonicotinohydrazide
and N -(2-methoxybenzylidene )isonicotinohydrazide.
The obtained yield of products would be compared (with
the same condition). Reaction mechanism of this synthesis is
nucleophilic addition by eliminating water. Methoxy group at 2-
methoxybenzaldehyde caused hindrance effect and made it is more
difficult to be attacked by a nucleophile. The structure of the
products were identified by UV spectrophotometry, IR
spectrophotometry, and IH_NMR spectrometry. The N-benzylideneisonicotinohydrazide
is produced as white crystal with 98.32% yield
and N-(2-methoxybenzylidene)isonicotinohydrazide is produced as
white crystal with 66.52% yield. As conclusion, synthesis of Nbenzylideneisonicotinohydrazide
gave yield higher than N-(2-methoxybenzylidene )isonicotinohydrazide. |
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