Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma
Background: Nasopharyngeal carcinoma (NPC) recurrency rate is still high despite patients receiving complete treatment. The response to treatment may vary depending on the type of histopathology and Epstein-Barr virus, however the mechanism remains unclear. Recent studies have found that there is a...
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id-langga.1194382023-01-11T07:09:05Z https://repository.unair.ac.id/119438/ Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma Muhtarum Yusuf, - Indriyadevi Indra, - Sri Herawati Juniati, - Yussy Afriani Dewi, - R Medicine (General) RF Otorhinolaryngology Background: Nasopharyngeal carcinoma (NPC) recurrency rate is still high despite patients receiving complete treatment. The response to treatment may vary depending on the type of histopathology and Epstein-Barr virus, however the mechanism remains unclear. Recent studies have found that there is a relationship between response to treatment and the presence of cancer stem cells (CSCs). CD44+ cancer stem cells may cause cancer cells to be resistant to treatment. Therefore, this cross-sectional study aims to determine the correlation between CD44 + cancer stem cell expression and the histopathological types of NPC. Method: Samples were obtained from NPC biopsies of type I, II, III patients (based on WHO histopathology criteria), who had not received prior treatment. CD44+ expression was examined using immunohistochemistry methods by staining CD44+ monoclonal antibodies. The degree of CD44+ cell membrane expression was based on the immunoreactive score scale or the Remmele index scale. Results: Most histopathological types were WHO type III (21 patients, 50%), followed by type II (18 patients, 42.86%), and type I (3 patients, 7.14%). CD44 + expression on type I showed one patient had moderate positive and two patients had a high-positive expression. In type II, 10 were moderate positive and eight were high-positive. In type III, one patient was low-positive, 11 were moderate positive and nine patients were high-positive. Statistical analysis showed that the CD44+ expression difference between the three histopathology types were not statistically significant. Conclusion: There were no correlations between CD44 + expression and histopathological type of NPC. Taylor & Francis 2020 Article PeerReviewed text en https://repository.unair.ac.id/119438/1/Bukti%20Korespondensi%201.pdf text en https://repository.unair.ac.id/119438/2/Karil%201.pdf text en https://repository.unair.ac.id/119438/3/Artikel%201.pdf text en https://repository.unair.ac.id/119438/4/C1%20Turnitin.pdf text en https://repository.unair.ac.id/119438/9/5.%20The%20analysis%20of%20titer%20antibody%20IgA%20VCA%20and%20IgA%20EBNA%20in%20NPC%20pateints.pdf text en https://repository.unair.ac.id/119438/10/Bukti%20Etik%201.pdf Muhtarum Yusuf, - and Indriyadevi Indra, - and Sri Herawati Juniati, - and Yussy Afriani Dewi, - (2020) Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma. F1000Research, 10 (678). pp. 1-13. ISSN 2046-1402 https://f1000research.com/articles/10-678 https://doi.org/10.12688/f1000research.53643.2 |
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R Medicine (General) RF Otorhinolaryngology Muhtarum Yusuf, - Indriyadevi Indra, - Sri Herawati Juniati, - Yussy Afriani Dewi, - Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
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Background: Nasopharyngeal carcinoma (NPC) recurrency rate is still high despite patients receiving complete treatment. The response to treatment may vary depending on the type of histopathology and Epstein-Barr virus, however the mechanism remains unclear. Recent studies have found that there is a relationship between response to treatment and the presence of cancer stem cells (CSCs). CD44+ cancer stem cells may cause cancer cells to be resistant to treatment. Therefore, this cross-sectional study aims to determine the correlation between CD44 + cancer stem cell expression and the histopathological types of NPC. Method: Samples were obtained from NPC biopsies of type I, II, III patients (based on WHO histopathology criteria), who had not received prior treatment. CD44+ expression was examined using immunohistochemistry methods by staining CD44+ monoclonal antibodies. The degree of CD44+ cell membrane expression was based on the immunoreactive score scale or the Remmele index scale. Results: Most histopathological types were WHO type III (21 patients, 50%), followed by type II (18 patients, 42.86%), and type I (3 patients, 7.14%). CD44 + expression on type I showed one patient had moderate positive and two patients had a high-positive expression. In type II, 10 were moderate positive and eight were high-positive. In type III, one patient was low-positive, 11 were moderate positive and nine patients were high-positive. Statistical analysis showed that the CD44+ expression difference between the three histopathology types were not statistically significant. Conclusion: There were no correlations between CD44 + expression and histopathological type of NPC. |
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Article PeerReviewed |
author |
Muhtarum Yusuf, - Indriyadevi Indra, - Sri Herawati Juniati, - Yussy Afriani Dewi, - |
author_facet |
Muhtarum Yusuf, - Indriyadevi Indra, - Sri Herawati Juniati, - Yussy Afriani Dewi, - |
author_sort |
Muhtarum Yusuf, - |
title |
Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
title_short |
Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
title_full |
Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
title_fullStr |
Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
title_full_unstemmed |
Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
title_sort |
correlation between cd44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
publisher |
Taylor & Francis |
publishDate |
2020 |
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https://repository.unair.ac.id/119438/1/Bukti%20Korespondensi%201.pdf https://repository.unair.ac.id/119438/2/Karil%201.pdf https://repository.unair.ac.id/119438/3/Artikel%201.pdf https://repository.unair.ac.id/119438/4/C1%20Turnitin.pdf https://repository.unair.ac.id/119438/9/5.%20The%20analysis%20of%20titer%20antibody%20IgA%20VCA%20and%20IgA%20EBNA%20in%20NPC%20pateints.pdf https://repository.unair.ac.id/119438/10/Bukti%20Etik%201.pdf https://repository.unair.ac.id/119438/ https://f1000research.com/articles/10-678 https://doi.org/10.12688/f1000research.53643.2 |
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