The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy:a randomized control trial
Background: Healing of chronic plantar ulcers in leprosy (CPUL) typically takes a long time due to impaired neurological function, thereby reducing the levels of growth factors and cytokines. Cytokines can be found in metabolite products from amniotic membrane stem cells. Chronic ulcers are frequent...
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Informa Healthcare
2018
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id-langga.1195872023-01-17T12:28:02Z https://repository.unair.ac.id/119587/ The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy:a randomized control trial Cita Rosita Sigit Prakoeswa, - F. R. Natallya, - D. Harnindya, - A. Thohiroh, - R. N. Oktaviyanti, - K. D. Pratiwi, - M. A. Rubianti, - B. Yogatri, - P. I. Primasari, - N. Herwanto, - Medhi Denisa Alinda, - B. H. Kusumaputra, - Linda Astari, - M. Yulianto Listiawan, - Indropo Agusni, - Fedik Abdul Rantam, - R Medicine (General) RL Dermatology Background: Healing of chronic plantar ulcers in leprosy (CPUL) typically takes a long time due to impaired neurological function, thereby reducing the levels of growth factors and cytokines. Cytokines can be found in metabolite products from amniotic membrane stem cells. Chronic ulcers are frequently characterized by high levels of reactive oxygen species. Vitamin E (α-tocopherol) is widely used in skin lesions, owing to its antioxidant and anti-inflammatory properties. Vitamin C also has antioxidant, anti-inflammatory, and collagen synthesis properties which are useful in wound healing. Herein, we compared the effects of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) alone and with vitamins C and E on healing of CPUL. Methods: In this randomized controlled trial, topical agents were applied every 3 days for up to 8 weeks. Ulcer size, side-effects, and possible complications were monitored weekly. Results: Healing percentage increased each week in all groups. Mean difference in ulcer size was highest in the hAMMSC-CM + vitamin E group, implying better progress of wound healing. There were no side-effects or complications. Conclusions: hAMMSC-CM + vitamin E is best for healing of CPUL. Informa Healthcare 2018 Article PeerReviewed text en https://repository.unair.ac.id/119587/1/Artikel.pdf text en https://repository.unair.ac.id/119587/2/Karil.pdf text en https://repository.unair.ac.id/119587/3/Similarity.pdf Cita Rosita Sigit Prakoeswa, - and F. R. Natallya, - and D. Harnindya, - and A. Thohiroh, - and R. N. Oktaviyanti, - and K. D. Pratiwi, - and M. A. Rubianti, - and B. Yogatri, - and P. I. Primasari, - and N. Herwanto, - and Medhi Denisa Alinda, - and B. H. Kusumaputra, - and Linda Astari, - and M. Yulianto Listiawan, - and Indropo Agusni, - and Fedik Abdul Rantam, - (2018) The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy:a randomized control trial. JOURNAL OF DERMATOLOGICAL TREATMENT, 29 (8). pp. 835-840. ISSN 0954-6634 https://www.tandfonline.com/doi/abs/10.1080/09546634.2018.1467541?journalCode=ijdt20 https://doi.org/10.1080/09546634.2018.1467541 |
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R Medicine (General) RL Dermatology Cita Rosita Sigit Prakoeswa, - F. R. Natallya, - D. Harnindya, - A. Thohiroh, - R. N. Oktaviyanti, - K. D. Pratiwi, - M. A. Rubianti, - B. Yogatri, - P. I. Primasari, - N. Herwanto, - Medhi Denisa Alinda, - B. H. Kusumaputra, - Linda Astari, - M. Yulianto Listiawan, - Indropo Agusni, - Fedik Abdul Rantam, - The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy:a randomized control trial |
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Background: Healing of chronic plantar ulcers in leprosy (CPUL) typically takes a long time due to impaired neurological function, thereby reducing the levels of growth factors and cytokines. Cytokines can be found in metabolite products from amniotic membrane stem cells. Chronic ulcers are frequently characterized by high levels of reactive oxygen species. Vitamin E (α-tocopherol) is widely used in skin lesions, owing to its antioxidant and anti-inflammatory properties. Vitamin C also has antioxidant, anti-inflammatory, and collagen synthesis properties which are useful in wound healing. Herein, we compared the effects of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) alone and with vitamins C and E on healing of CPUL. Methods: In this randomized controlled trial, topical agents were applied every 3 days for up to 8 weeks. Ulcer size, side-effects, and possible complications were monitored weekly. Results: Healing percentage increased each week in all groups. Mean difference in ulcer size was highest in the hAMMSC-CM + vitamin E group, implying better progress of wound healing. There were no side-effects or complications. Conclusions: hAMMSC-CM + vitamin E is best for healing of CPUL. |
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Article PeerReviewed |
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Cita Rosita Sigit Prakoeswa, - F. R. Natallya, - D. Harnindya, - A. Thohiroh, - R. N. Oktaviyanti, - K. D. Pratiwi, - M. A. Rubianti, - B. Yogatri, - P. I. Primasari, - N. Herwanto, - Medhi Denisa Alinda, - B. H. Kusumaputra, - Linda Astari, - M. Yulianto Listiawan, - Indropo Agusni, - Fedik Abdul Rantam, - |
author_facet |
Cita Rosita Sigit Prakoeswa, - F. R. Natallya, - D. Harnindya, - A. Thohiroh, - R. N. Oktaviyanti, - K. D. Pratiwi, - M. A. Rubianti, - B. Yogatri, - P. I. Primasari, - N. Herwanto, - Medhi Denisa Alinda, - B. H. Kusumaputra, - Linda Astari, - M. Yulianto Listiawan, - Indropo Agusni, - Fedik Abdul Rantam, - |
author_sort |
Cita Rosita Sigit Prakoeswa, - |
title |
The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy:a randomized control trial |
title_short |
The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy:a randomized control trial |
title_full |
The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy:a randomized control trial |
title_fullStr |
The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy:a randomized control trial |
title_full_unstemmed |
The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy:a randomized control trial |
title_sort |
efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hammsc-cm) and a mixture of topical hammsc-cm + vitamin c and hammsc-cm + vitamin e on chronic plantar ulcers in leprosy:a randomized control trial |
publisher |
Informa Healthcare |
publishDate |
2018 |
url |
https://repository.unair.ac.id/119587/1/Artikel.pdf https://repository.unair.ac.id/119587/2/Karil.pdf https://repository.unair.ac.id/119587/3/Similarity.pdf https://repository.unair.ac.id/119587/ https://www.tandfonline.com/doi/abs/10.1080/09546634.2018.1467541?journalCode=ijdt20 https://doi.org/10.1080/09546634.2018.1467541 |
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1756410706182275072 |