Nefroprotector Effect Of Curcumin (Curcuma Longa) And Vitamin E (Α-Tocopherol) In Wistar Strain Rats After Cisplatin Treatment
Objective: To analyze the effect of curcumin and vitamin E on kidney function and inflammatory response of Wistar strain rats that received cisplatin. Material & Methods: An experimental laboratory study with a post-test only control design, using male Wistar strain rats (Rattus norwegicus). Rat...
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Universitas Airlangga
2021
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id-langga.1197592023-02-01T03:01:20Z https://repository.unair.ac.id/119759/ Nefroprotector Effect Of Curcumin (Curcuma Longa) And Vitamin E (Α-Tocopherol) In Wistar Strain Rats After Cisplatin Treatment Binsar Marshall Maranatha Sirait, - Wahjoe Djatisoesanto, - Soetojo, - R Medicine (General) RC870-923 Diseases of the genitourinary system. Urology Objective: To analyze the effect of curcumin and vitamin E on kidney function and inflammatory response of Wistar strain rats that received cisplatin. Material & Methods: An experimental laboratory study with a post-test only control design, using male Wistar strain rats (Rattus norwegicus). Rats were randomized using the simple randomized sampling method. Samples were treated with cisplatin 5 mg/kg (positive control group), vitamin E 100 mg/kg, curcumin 100 mg/kg body, and a combination of both (treatment group), to evaluate its effect on and kidney function and inflammatory response as measured by tumor necrosis factor-α (TNF-α), blood urea nitrogen (BUN) and serum creatinine. Results: There were differences in TNF-α levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p<0.05). Further analysis showed that there was a significant difference between the treatment group that received vitamin E and curcumin from the treatment group that received a combination of both (P<0.05). In addition, there were differences in BUN and serum creatinine levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p<0.05). However, there was no significant difference in BUN levels in the treatment group that received vitamin E with the treatment group that received curcumin or a combination of both (p>0.05). No differences were found in serum creatinine levels between treatment groups receiving vitamin E, curcumin, or a combination of both. Conclusion: Vitamin E 100 mg/kg, curcumin 100 mg/kg, and the combination of both have a nephroprotector feature in Wistar rats exposed to cisplatin. Universitas Airlangga 2021 Article PeerReviewed text en https://repository.unair.ac.id/119759/2/Karil%2013.pdf text en https://repository.unair.ac.id/119759/3/Artikel%2013.pdf text en https://repository.unair.ac.id/119759/4/Similarity%2013.pdf Binsar Marshall Maranatha Sirait, - and Wahjoe Djatisoesanto, - and Soetojo, - (2021) Nefroprotector Effect Of Curcumin (Curcuma Longa) And Vitamin E (Α-Tocopherol) In Wistar Strain Rats After Cisplatin Treatment. Indonesian Journal of Urology, 28 (1). pp. 98-108. ISSN 0853-442X https://juri.urologi.or.id/juri/article/view/704 https://doi.org/10.32421/juri.v28i1.704 |
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R Medicine (General) RC870-923 Diseases of the genitourinary system. Urology Binsar Marshall Maranatha Sirait, - Wahjoe Djatisoesanto, - Soetojo, - Nefroprotector Effect Of Curcumin (Curcuma Longa) And Vitamin E (Α-Tocopherol) In Wistar Strain Rats After Cisplatin Treatment |
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Objective: To analyze the effect of curcumin and vitamin E on kidney function and inflammatory response of Wistar strain rats that received cisplatin. Material & Methods: An experimental laboratory study with a post-test only control design, using male Wistar strain rats (Rattus norwegicus). Rats were randomized using the simple randomized sampling method. Samples were treated with cisplatin 5 mg/kg (positive control group), vitamin E 100 mg/kg, curcumin 100 mg/kg body, and a combination of both (treatment group), to evaluate its effect on and kidney function and inflammatory response as measured by tumor necrosis factor-α (TNF-α), blood urea nitrogen (BUN) and serum creatinine. Results: There were differences in TNF-α levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p<0.05). Further analysis showed that there was a significant difference between the treatment group that received vitamin E and curcumin from the treatment group that received a combination of both (P<0.05). In addition, there were differences in BUN and serum creatinine levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p<0.05). However, there was no significant difference in BUN levels in the treatment group that received vitamin E with the treatment group that received curcumin or a combination of both (p>0.05). No differences were found in serum creatinine levels between treatment groups receiving vitamin E, curcumin, or a combination of both. Conclusion: Vitamin E 100 mg/kg, curcumin 100 mg/kg, and the combination of both have a nephroprotector feature in Wistar rats exposed to cisplatin. |
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Article PeerReviewed |
author |
Binsar Marshall Maranatha Sirait, - Wahjoe Djatisoesanto, - Soetojo, - |
author_facet |
Binsar Marshall Maranatha Sirait, - Wahjoe Djatisoesanto, - Soetojo, - |
author_sort |
Binsar Marshall Maranatha Sirait, - |
title |
Nefroprotector Effect Of Curcumin (Curcuma Longa) And Vitamin E (Α-Tocopherol) In Wistar Strain Rats After Cisplatin Treatment |
title_short |
Nefroprotector Effect Of Curcumin (Curcuma Longa) And Vitamin E (Α-Tocopherol) In Wistar Strain Rats After Cisplatin Treatment |
title_full |
Nefroprotector Effect Of Curcumin (Curcuma Longa) And Vitamin E (Α-Tocopherol) In Wistar Strain Rats After Cisplatin Treatment |
title_fullStr |
Nefroprotector Effect Of Curcumin (Curcuma Longa) And Vitamin E (Α-Tocopherol) In Wistar Strain Rats After Cisplatin Treatment |
title_full_unstemmed |
Nefroprotector Effect Of Curcumin (Curcuma Longa) And Vitamin E (Α-Tocopherol) In Wistar Strain Rats After Cisplatin Treatment |
title_sort |
nefroprotector effect of curcumin (curcuma longa) and vitamin e (α-tocopherol) in wistar strain rats after cisplatin treatment |
publisher |
Universitas Airlangga |
publishDate |
2021 |
url |
https://repository.unair.ac.id/119759/2/Karil%2013.pdf https://repository.unair.ac.id/119759/3/Artikel%2013.pdf https://repository.unair.ac.id/119759/4/Similarity%2013.pdf https://repository.unair.ac.id/119759/ https://juri.urologi.or.id/juri/article/view/704 https://doi.org/10.32421/juri.v28i1.704 |
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1757049658693124096 |