Relationship between CD4 levels and mucocutaneous manifestations in HIV-AIDS patients at Dr. Soetomo General Academic Teaching Hospital, Surabaya, Indonesia

• Main Authors: Citra Dwi Harningtyas, Citra, Damayanti, Damayanti, Maylita Sari, Maylita, Muhammad Yulianto Listiawan, Muhammad, Diah Mira Indramaya, Diah, Linda Astari, Linda, Budi Utomo, Budi, Dwi Murtiastutik, Dwi, Setyana Widyantari, Setyana, Astindari, Astindari, Afif Nurul Hidayati, Afif
• Format: Article PeerReviewed
• Language: English; English; Indonesian; English
• Published: Sanglah General Hospital
• Subjects: R5-920 Medicine (General)
• Online Access: https://repository.unair.ac.id/120070/1/13.%20artikel.pdf; https://repository.unair.ac.id/120070/2/13.%20turnitin.pdf; https://repository.unair.ac.id/120070/3/13.%20karil.pdf; https://repository.unair.ac.id/120070/4/13.%20koresponden.pdf; https://repository.unair.ac.id/120070/; https://www.balimedicaljournal.org/index.php/bmj/article/view/3385; https://doi.org/10.15562/bmj.v11i1.3416
• Institution: Universitas Airlangga

Abstract Background: CD4 can assess the immune status of a patient with HIV, and this is considered the standard way of assessing and characterizing the severity of HIV-related immunodeficiency. CD4 cell counts are associated with increased mucocutaneous manifestations. This study aims to explain the relationship between CD4 and mucocutaneous manifestations in HIV-AIDS patients. Methods: This study is analytical with a retrospective cross-sectional design. The data of the present study was obtained from a number of 614 HIV-AIDS patients with mucocutaneous manifestations, but only 149 patients met the inclusion criteria, including the CD4 level data. Results: The majority of the patients in this study were male (74.5%), which includes patients under the age group of 25-49 years (70.5%). The most common risk factor was heterosexuality (48.3%). Most CD4 levels were in the CD4 group < 200 (64.4%). Based on the distribution of mucocutaneous manifestations, the various cases were reported as infections (55.8%). Pyoderma and syphilis were significantly associated with CD4 counts ≥ 200 cells/mm3 with a risk of 3.7 and 7.8 times than CD4 cells < 200 cells / mm3. On the other hand, candidiasis was higher in CD4 count < 200 cells/mm3 with a significant difference and a risk of 0.3 times compared to CD4 count ≥ 200 cells/mm3. Conclusion: Several mucocutaneous manifestations can be considered predictors of advanced immunosuppression (low CD4 level), which were pyoderma, syphilis, and candidiasis in this study.