Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole.
Abstract Background: Oral Candidiasis (OC) still mainly oportunistic infection problem in HIV/AIDS Patients. Due to increasing report of fluconazole resistant as common antifungal drugs nowadays, there have been many studies focusing on natural substances and its antifungal properties. In this st...
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id-langga.1200872023-02-25T09:10:02Z https://repository.unair.ac.id/120087/ Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole. Dwi Murtiastutik, Dwi Cita Rosita Sigit Prakoswa, Cita Indah Setyawati Tantular, Indah Yusuf Wibisono, Yusuf Afif Nurul Hidayati, Afif Sawitri, Sawitri Muhammad Yulianto Listiawan, Muhammad R5-920 Medicine (General) Abstract Background: Oral Candidiasis (OC) still mainly oportunistic infection problem in HIV/AIDS Patients. Due to increasing report of fluconazole resistant as common antifungal drugs nowadays, there have been many studies focusing on natural substances and its antifungal properties. In this study, a form of green tea extract, named Epigallocathechingallate (EGCG) 1,25% were examined for their in vitro antifungal activity against Candida sp in comparison to fluconazole (2 mg/ml) as standard antifungal agents.Objective: To evaluate the antifungal activity of EGCG in compare with fluconazole against Candida isolates taken from HIV / AIDS patients with OC. Methods: Fourty Candida sp. isolates taken from HIV / AIDS patients with OC in the Outpatient Unit and Inpatient Installation of the Infectious Disease Intermediate Care Unit (UPIPI) Dr. Soetomo, Surabaya. Antifungal activity were evaluated by using microdilution tests. Results: The microdilution test revealed the MIC of EGCG for all Candida sp. was 0.625%, while the MIC of fluconazole was 100% for all Candida sp. There was significant difference (p <0.05) between the MIC values for Candida sp. by fluconazole and EGCG. The MFC values of EGCG was 50%, while value of fluconazole MFC was 100%. Conclusion: Antifungal activity of EGCG with fungistatic and fungicidal effect is better than fluconazole. Institute of Medico-Legal Publications Article PeerReviewed text en https://repository.unair.ac.id/120087/1/17.%20artikel.pdf text id https://repository.unair.ac.id/120087/3/17.%20Epigallocathecingallate%20%28EGCG%29%20Antifungal%20Properties%20for%20Candida.pdf text en https://repository.unair.ac.id/120087/5/17.%20Epigallocathecingallate.pdf Dwi Murtiastutik, Dwi and Cita Rosita Sigit Prakoswa, Cita and Indah Setyawati Tantular, Indah and Yusuf Wibisono, Yusuf and Afif Nurul Hidayati, Afif and Sawitri, Sawitri and Muhammad Yulianto Listiawan, Muhammad Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole. Indian Journal of Forensic Medicine & Toxicology, 15 (1). ISSN 09739122 https://medicopublication.com/index.php/ijfmt/article/view/13549 //doi.org/10.37506/ijfmt.v15i1.13549 |
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R5-920 Medicine (General) Dwi Murtiastutik, Dwi Cita Rosita Sigit Prakoswa, Cita Indah Setyawati Tantular, Indah Yusuf Wibisono, Yusuf Afif Nurul Hidayati, Afif Sawitri, Sawitri Muhammad Yulianto Listiawan, Muhammad Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole. |
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Abstract
Background: Oral Candidiasis (OC) still mainly oportunistic infection problem in HIV/AIDS Patients.
Due to increasing report of fluconazole resistant as common antifungal drugs nowadays, there have been
many studies focusing on natural substances and its antifungal properties. In this study, a form of green tea
extract, named Epigallocathechingallate (EGCG) 1,25% were examined for their in vitro antifungal activity against Candida sp in comparison to fluconazole (2 mg/ml) as standard antifungal agents.Objective:
To evaluate the antifungal activity of EGCG in compare with fluconazole against Candida isolates taken
from HIV / AIDS patients with OC. Methods: Fourty Candida sp. isolates taken from HIV / AIDS patients
with OC in the Outpatient Unit and Inpatient Installation of the Infectious Disease Intermediate Care Unit
(UPIPI) Dr. Soetomo, Surabaya. Antifungal activity were evaluated by using microdilution tests. Results:
The microdilution test revealed the MIC of EGCG for all Candida sp. was 0.625%, while the MIC of
fluconazole was 100% for all Candida sp. There was significant difference (p <0.05) between the MIC
values for Candida sp. by fluconazole and EGCG. The MFC values of EGCG was 50%, while value of
fluconazole MFC was 100%. Conclusion: Antifungal activity of EGCG with fungistatic and fungicidal
effect is better than fluconazole. |
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Article PeerReviewed |
author |
Dwi Murtiastutik, Dwi Cita Rosita Sigit Prakoswa, Cita Indah Setyawati Tantular, Indah Yusuf Wibisono, Yusuf Afif Nurul Hidayati, Afif Sawitri, Sawitri Muhammad Yulianto Listiawan, Muhammad |
author_facet |
Dwi Murtiastutik, Dwi Cita Rosita Sigit Prakoswa, Cita Indah Setyawati Tantular, Indah Yusuf Wibisono, Yusuf Afif Nurul Hidayati, Afif Sawitri, Sawitri Muhammad Yulianto Listiawan, Muhammad |
author_sort |
Dwi Murtiastutik, Dwi |
title |
Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole. |
title_short |
Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole. |
title_full |
Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole. |
title_fullStr |
Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole. |
title_full_unstemmed |
Epigallocathecingallate (EGCG) Antifungal Properties for Candida Isolates from HIV/AIDS Patients with Oral Candidiasis in Compare with Fluconazole. |
title_sort |
epigallocathecingallate (egcg) antifungal properties for candida isolates from hiv/aids patients with oral candidiasis in compare with fluconazole. |
publisher |
Institute of Medico-Legal Publications |
url |
https://repository.unair.ac.id/120087/1/17.%20artikel.pdf https://repository.unair.ac.id/120087/3/17.%20Epigallocathecingallate%20%28EGCG%29%20Antifungal%20Properties%20for%20Candida.pdf https://repository.unair.ac.id/120087/5/17.%20Epigallocathecingallate.pdf https://repository.unair.ac.id/120087/ https://medicopublication.com/index.php/ijfmt/article/view/13549 |
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