LONG - TERM EFFECTS OF TOPICAL AMNIOTIC MEMBRANE STEM CELL METABOLITE PRODUCT (AMSC-MP) AND FRACTIONAL CO2 LASER IN PHOTOAGING
Abstract Background: Photoaging causes wrinkles, lentigines, keratoses, dyspigmentation, telangiectasia, decreased elasticity, rough texture, and pale color. Facial wrinkles and mottled skin can negatively affect perceived attractiveness, self-esteem, personality, and level of acceptance. Stem cell...
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Department/Staf Medik Fungsional Dermatovenereology of the Faculty of Medicine, Airlangga University - Dr. Soetomo Academic General Hospital Surabaya.
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id-langga.1200892023-02-25T09:10:42Z https://repository.unair.ac.id/120089/ LONG - TERM EFFECTS OF TOPICAL AMNIOTIC MEMBRANE STEM CELL METABOLITE PRODUCT (AMSC-MP) AND FRACTIONAL CO2 LASER IN PHOTOAGING Dyah Ayu Pitasari, Dyah Afif Nurul Hidayati, Afif Muhammad Yulianto Listiawan, Muhammad Sawitri, Sawitri Damayanti, Damayanti Cita Rosita Sigit Prakoeswa, Cita R5-920 Medicine (General) Abstract Background: Photoaging causes wrinkles, lentigines, keratoses, dyspigmentation, telangiectasia, decreased elasticity, rough texture, and pale color. Facial wrinkles and mottled skin can negatively affect perceived attractiveness, self-esteem, personality, and level of acceptance. Stem cells are important cells in the skin, and they are the source for continuous regeneration of the epidermis. It can be extracted from many sources, including amnion. Amnion membrane stem cell (AMSC) can be cultured and secretes metabolite product, and it can rejuvenate aging skin. Laser-Assisted Drug Delivery (LADD) involves selective destruction of the layers of the epidermis and dermis to allow penetration and absorption of topical drugs as well as large molecular weight drugs such as stem cells. Purpose: To evaluate the long-term effects of topical administration of AMSC metabolite products (AMSC -MP) and fractional CO2 laser on the clinical improvement of photoaging compared to previous skin conditions. Methods: This was an observational study which was aimed to evaluate the long-term effects of clinical improvement after topical therapy of AMSC-MP and fractional CO2 laser in patients with photoaging. Results: The results of the analysis showed a decrease in wrinkles, dark spots, skin tone, and pores. Conclusion: Based on Janus-II® assessment, there was improvement degrees of wrinkles, dark spots, and pores in patients with photoaging who received fractional CO2laser fractional for 12 weeks. There were no side effects found in this study. Department/Staf Medik Fungsional Dermatovenereology of the Faculty of Medicine, Airlangga University - Dr. Soetomo Academic General Hospital Surabaya. Article PeerReviewed text en https://repository.unair.ac.id/120089/1/23.%20artikel.pdf text id https://repository.unair.ac.id/120089/3/23.%20LONG%20-%20TERM%20EFFECTS%20OF%20TOPICAL%20AMNIOTIC%20MEMBRANE.pdf text en https://repository.unair.ac.id/120089/5/23.%20LONG%20-%20TERM%20EFFECTS%20OF%20TOPICAL%20AMNIOTIC%20MEMBRANE.pdf Dyah Ayu Pitasari, Dyah and Afif Nurul Hidayati, Afif and Muhammad Yulianto Listiawan, Muhammad and Sawitri, Sawitri and Damayanti, Damayanti and Cita Rosita Sigit Prakoeswa, Cita LONG - TERM EFFECTS OF TOPICAL AMNIOTIC MEMBRANE STEM CELL METABOLITE PRODUCT (AMSC-MP) AND FRACTIONAL CO2 LASER IN PHOTOAGING. Berkala Ilmu Kesehatan Kulit dan Kelamin, 32 (1). ISSN 1978-4279 https://e-journal.unair.ac.id/BIKK/article/view/15291 //dx.doi.org/10.20473/bikk.V32.1.2020.27-32 |
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R5-920 Medicine (General) Dyah Ayu Pitasari, Dyah Afif Nurul Hidayati, Afif Muhammad Yulianto Listiawan, Muhammad Sawitri, Sawitri Damayanti, Damayanti Cita Rosita Sigit Prakoeswa, Cita LONG - TERM EFFECTS OF TOPICAL AMNIOTIC MEMBRANE STEM CELL METABOLITE PRODUCT (AMSC-MP) AND FRACTIONAL CO2 LASER IN PHOTOAGING |
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Abstract
Background: Photoaging causes wrinkles, lentigines, keratoses, dyspigmentation, telangiectasia, decreased elasticity, rough texture, and pale color. Facial wrinkles and mottled skin can negatively affect perceived attractiveness, self-esteem, personality, and level of acceptance. Stem cells are important cells in the skin, and they are the source for continuous regeneration of the epidermis. It can be extracted from many sources, including amnion. Amnion membrane stem cell (AMSC) can be cultured and secretes metabolite product, and it can rejuvenate aging skin. Laser-Assisted Drug Delivery (LADD) involves selective destruction of the layers of the epidermis and dermis to allow penetration and absorption of topical drugs as well as large molecular weight drugs such as stem cells. Purpose: To evaluate the long-term effects of topical administration of AMSC metabolite products (AMSC -MP) and fractional CO2 laser on the clinical improvement of photoaging compared to previous skin conditions. Methods: This was an observational study which was aimed to evaluate the long-term effects of clinical improvement after topical therapy of AMSC-MP and fractional CO2 laser in patients with photoaging. Results: The results of the analysis showed a decrease in wrinkles, dark spots, skin tone, and pores. Conclusion: Based on Janus-II® assessment, there was improvement degrees of wrinkles, dark spots, and pores in patients with photoaging who received fractional CO2laser fractional for 12 weeks. There were no side effects found in this study. |
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Article PeerReviewed |
author |
Dyah Ayu Pitasari, Dyah Afif Nurul Hidayati, Afif Muhammad Yulianto Listiawan, Muhammad Sawitri, Sawitri Damayanti, Damayanti Cita Rosita Sigit Prakoeswa, Cita |
author_facet |
Dyah Ayu Pitasari, Dyah Afif Nurul Hidayati, Afif Muhammad Yulianto Listiawan, Muhammad Sawitri, Sawitri Damayanti, Damayanti Cita Rosita Sigit Prakoeswa, Cita |
author_sort |
Dyah Ayu Pitasari, Dyah |
title |
LONG - TERM EFFECTS OF TOPICAL AMNIOTIC MEMBRANE STEM CELL METABOLITE PRODUCT (AMSC-MP) AND FRACTIONAL CO2 LASER IN PHOTOAGING |
title_short |
LONG - TERM EFFECTS OF TOPICAL AMNIOTIC MEMBRANE STEM CELL METABOLITE PRODUCT (AMSC-MP) AND FRACTIONAL CO2 LASER IN PHOTOAGING |
title_full |
LONG - TERM EFFECTS OF TOPICAL AMNIOTIC MEMBRANE STEM CELL METABOLITE PRODUCT (AMSC-MP) AND FRACTIONAL CO2 LASER IN PHOTOAGING |
title_fullStr |
LONG - TERM EFFECTS OF TOPICAL AMNIOTIC MEMBRANE STEM CELL METABOLITE PRODUCT (AMSC-MP) AND FRACTIONAL CO2 LASER IN PHOTOAGING |
title_full_unstemmed |
LONG - TERM EFFECTS OF TOPICAL AMNIOTIC MEMBRANE STEM CELL METABOLITE PRODUCT (AMSC-MP) AND FRACTIONAL CO2 LASER IN PHOTOAGING |
title_sort |
long - term effects of topical amniotic membrane stem cell metabolite product (amsc-mp) and fractional co2 laser in photoaging |
publisher |
Department/Staf Medik Fungsional Dermatovenereology of the Faculty of Medicine, Airlangga University - Dr. Soetomo Academic General Hospital Surabaya. |
url |
https://repository.unair.ac.id/120089/1/23.%20artikel.pdf https://repository.unair.ac.id/120089/3/23.%20LONG%20-%20TERM%20EFFECTS%20OF%20TOPICAL%20AMNIOTIC%20MEMBRANE.pdf https://repository.unair.ac.id/120089/5/23.%20LONG%20-%20TERM%20EFFECTS%20OF%20TOPICAL%20AMNIOTIC%20MEMBRANE.pdf https://repository.unair.ac.id/120089/ https://e-journal.unair.ac.id/BIKK/article/view/15291 |
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