Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis

• Main Authors: Johanes Nugroho Eko Putranto, Johanes, Ruth Gunadi, Ruth
• Format: Article PeerReviewed
• Language: English; English; Indonesian; English
• Published: Hindawi
• Subjects: R5-920 Medicine (General)
• Online Access: https://repository.unair.ac.id/120140/1/23%20artikel.pdf; https://repository.unair.ac.id/120140/2/23%20turnitin.pdf; https://repository.unair.ac.id/120140/3/23%20karil.pdf; https://repository.unair.ac.id/120140/4/23.%20Acute%20Limb%20Ischemia%20in%20the%20Young.pdf; https://repository.unair.ac.id/120140/; https://www.hindawi.com/journals/cric/2021/2563578/; https://doi.org/10.1155/2021/2563578
• Institution: Universitas Airlangga

Abstract Acute limb ischemia (ALI) is rarely observed in young populations. The hypercoagulable state is a notable cause of ALI other than artery disease progression and cardiac embolization. A hypercoagulable state occurs in essential thrombocytosis because of the overproduction of hematopoietic cells secondary to the mutation of the JAK2, CALR, or MPL genes. We report a rare case of a 37-year-old woman presenting with Rutherford IIA ALI in the left lower extremity. Laboratory data revealed she had a platelet count reaching up to 1.38 mil/μL, with other blood profiles being normal. A JAK2 mutation examination was later performed and proved positive. After careful management with catheter-directed thrombolysis, surgical thrombectomy, and cytoreductive therapy using hydroxyurea, the symptoms subsided and eventually restored the patient to physical activity in less than one month.