Evaluation of the PaO2/FiO2 Ratio as a Risk Factor for Hypoxemia against Septicemia Mortality in Children who Treated at Dr. Soetomo General Hospital

Background: Severe septicemia can result in impaired oxygen perfusion to the tissues. The PaO2/FiO2 ratio (P/F ratio) is one of the measurement parameters for hypoxemia. This study aims to evaluate the P/F ratio as a risk factor for hypoxemia against septicemia mortality in children. Method: An obse...

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Main Authors: Yuli Astika, -, Arina Setyaningtyas, -, Dominicus Husada, -, Retno Asih Setyoningrum, -
Format: Article PeerReviewed
Language:English
English
English
English
Published: Institute of Medico-legal Publications 2021
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Online Access:https://repository.unair.ac.id/120278/1/Karil%205.pdf
https://repository.unair.ac.id/120278/2/Artikel%205.pdf
https://repository.unair.ac.id/120278/3/Bukti%20Etik%205.pdf
https://repository.unair.ac.id/120278/4/Similarity%205.pdf
https://repository.unair.ac.id/120278/
https://medicopublication.com/index.php/ijfmt/article/view/17142
https://doi.org/10.37506/ijfmt.v15i4.17142
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spelling id-langga.1202782023-03-06T03:58:06Z https://repository.unair.ac.id/120278/ Evaluation of the PaO2/FiO2 Ratio as a Risk Factor for Hypoxemia against Septicemia Mortality in Children who Treated at Dr. Soetomo General Hospital Yuli Astika, - Arina Setyaningtyas, - Dominicus Husada, - Retno Asih Setyoningrum, - R Medicine (General) RJ Pediatrics Background: Severe septicemia can result in impaired oxygen perfusion to the tissues. The PaO2/FiO2 ratio (P/F ratio) is one of the measurement parameters for hypoxemia. This study aims to evaluate the P/F ratio as a risk factor for hypoxemia against septicemia mortality in children. Method: An observational with a prospective cohort design was conducted. Thirty-six patients with septicemia, consisting of 18 patients who living (survivor) and 18 patients who died (non-survivor). The P/F ratio is obtained based on blood gas analysis carried out in the first 24 hours of treatment recorded on medical records and calculated manually. The P/F ratio has an area under the curve (AUC) of 0.83 (95% CI 0.71–0.95) with a cut-off of 226. Septicemia children with P/F ratio < 226 who have a mortality risk of up to 6.9 times (RR 6.9; 95% CI 1.719-27.957; p= 0.005) with sensitivity 72.70%; specificity 72.20%; PPV 76.19%; NPV 68.42%. The mean P/F ratio in the non-survivor group was significantly lower than the survivor group 161.60 (95% CI 1.05) compared to 391.09 (95% CI 2.13); p= 0.005). Conclusion: The P/F ratio can be a risk factor for hypoxemia on septicemia mortality. Institute of Medico-legal Publications 2021 Article PeerReviewed text en https://repository.unair.ac.id/120278/1/Karil%205.pdf text en https://repository.unair.ac.id/120278/2/Artikel%205.pdf text en https://repository.unair.ac.id/120278/3/Bukti%20Etik%205.pdf text en https://repository.unair.ac.id/120278/4/Similarity%205.pdf Yuli Astika, - and Arina Setyaningtyas, - and Dominicus Husada, - and Retno Asih Setyoningrum, - (2021) Evaluation of the PaO2/FiO2 Ratio as a Risk Factor for Hypoxemia against Septicemia Mortality in Children who Treated at Dr. Soetomo General Hospital. Indian Journal of Forensic Medicine & Toxicology, 15 (4). pp. 2913-2920. ISSN 0973-9130 https://medicopublication.com/index.php/ijfmt/article/view/17142 https://doi.org/10.37506/ijfmt.v15i4.17142
institution Universitas Airlangga
building Universitas Airlangga Library
continent Asia
country Indonesia
Indonesia
content_provider Universitas Airlangga Library
collection UNAIR Repository
language English
English
English
English
topic R Medicine (General)
RJ Pediatrics
spellingShingle R Medicine (General)
RJ Pediatrics
Yuli Astika, -
Arina Setyaningtyas, -
Dominicus Husada, -
Retno Asih Setyoningrum, -
Evaluation of the PaO2/FiO2 Ratio as a Risk Factor for Hypoxemia against Septicemia Mortality in Children who Treated at Dr. Soetomo General Hospital
description Background: Severe septicemia can result in impaired oxygen perfusion to the tissues. The PaO2/FiO2 ratio (P/F ratio) is one of the measurement parameters for hypoxemia. This study aims to evaluate the P/F ratio as a risk factor for hypoxemia against septicemia mortality in children. Method: An observational with a prospective cohort design was conducted. Thirty-six patients with septicemia, consisting of 18 patients who living (survivor) and 18 patients who died (non-survivor). The P/F ratio is obtained based on blood gas analysis carried out in the first 24 hours of treatment recorded on medical records and calculated manually. The P/F ratio has an area under the curve (AUC) of 0.83 (95% CI 0.71–0.95) with a cut-off of 226. Septicemia children with P/F ratio < 226 who have a mortality risk of up to 6.9 times (RR 6.9; 95% CI 1.719-27.957; p= 0.005) with sensitivity 72.70%; specificity 72.20%; PPV 76.19%; NPV 68.42%. The mean P/F ratio in the non-survivor group was significantly lower than the survivor group 161.60 (95% CI 1.05) compared to 391.09 (95% CI 2.13); p= 0.005). Conclusion: The P/F ratio can be a risk factor for hypoxemia on septicemia mortality.
format Article
PeerReviewed
author Yuli Astika, -
Arina Setyaningtyas, -
Dominicus Husada, -
Retno Asih Setyoningrum, -
author_facet Yuli Astika, -
Arina Setyaningtyas, -
Dominicus Husada, -
Retno Asih Setyoningrum, -
author_sort Yuli Astika, -
title Evaluation of the PaO2/FiO2 Ratio as a Risk Factor for Hypoxemia against Septicemia Mortality in Children who Treated at Dr. Soetomo General Hospital
title_short Evaluation of the PaO2/FiO2 Ratio as a Risk Factor for Hypoxemia against Septicemia Mortality in Children who Treated at Dr. Soetomo General Hospital
title_full Evaluation of the PaO2/FiO2 Ratio as a Risk Factor for Hypoxemia against Septicemia Mortality in Children who Treated at Dr. Soetomo General Hospital
title_fullStr Evaluation of the PaO2/FiO2 Ratio as a Risk Factor for Hypoxemia against Septicemia Mortality in Children who Treated at Dr. Soetomo General Hospital
title_full_unstemmed Evaluation of the PaO2/FiO2 Ratio as a Risk Factor for Hypoxemia against Septicemia Mortality in Children who Treated at Dr. Soetomo General Hospital
title_sort evaluation of the pao2/fio2 ratio as a risk factor for hypoxemia against septicemia mortality in children who treated at dr. soetomo general hospital
publisher Institute of Medico-legal Publications
publishDate 2021
url https://repository.unair.ac.id/120278/1/Karil%205.pdf
https://repository.unair.ac.id/120278/2/Artikel%205.pdf
https://repository.unair.ac.id/120278/3/Bukti%20Etik%205.pdf
https://repository.unair.ac.id/120278/4/Similarity%205.pdf
https://repository.unair.ac.id/120278/
https://medicopublication.com/index.php/ijfmt/article/view/17142
https://doi.org/10.37506/ijfmt.v15i4.17142
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