Potency of Mycotoxin Binders on MDA Level, Expressions of Caspase 9 and Caspase 3 in The Uterus of Mice Exposed to Zearalenone
This study examined effect of mycotoxin binder administered to female mice exposed to zearalenon on apoptosis incidence by observe at MDA, Caspase 9 and 3 levels in mice uterus. Negative control group (K-) was not exposed to zearalenon and without the administration of mycotoxin binders, positive co...
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University of Mosul - College of Veterinary Medicine
2017
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id-langga.1232252023-04-13T03:39:32Z https://repository.unair.ac.id/123225/ Potency of Mycotoxin Binders on MDA Level, Expressions of Caspase 9 and Caspase 3 in The Uterus of Mice Exposed to Zearalenone Abdul Samik, - Erma Safitri, - SF405.5-407 Laboratory animals SF910 Other diseases and conditions This study examined effect of mycotoxin binder administered to female mice exposed to zearalenon on apoptosis incidence by observe at MDA, Caspase 9 and 3 levels in mice uterus. Negative control group (K-) was not exposed to zearalenon and without the administration of mycotoxin binders, positive control group (K+) exposed to zearalenon of 0.1 mg/head/day and without the provision of mycotoxin binders; and treatment groups (P1, P2, P3) were exposed to zearalenon 0.1 mg/head/day by providing mycotoxin binders each 0.5; 1; 2 mg/head/day. Zearalenon and mycotoxinbinders administration was conducted for 10 days. Results on MDA level were as follows 15.48 ± 0.50 (K-), 45.59 ± 0.50 (K+), 34.92 ± 3.38 (P1), 27.72 ± 1.25 and 23.89 ± 3.74. Caspase 9 levels showed the following results: 0.3 ± 0.60 (K), 8.3 ± 0.90 (K+), 3.6 ± 0.41 (P1), 3.3 ± 0.34 (P2) and 2.8 ± 0.28 (P3), while the levels of Caspase3 were as follows: 3.35 ± 0.44 (K-), 12.5 ± 0.66 (K+), 3.6 ± 0.41 (P1), 4.80 ± 0.43 (P2) and 3.85 ± 0.50 (P3). In conclusion, mycotoxin binders may lower malondialdehyde (MDA) level and the expression of caspase 9 and caspase3 in the uterus of mice exposed to zearalenon. University of Mosul - College of Veterinary Medicine 2017-02 Article PeerReviewed text en https://repository.unair.ac.id/123225/2/Artikel_35_Erma_Safitri.pdf text en https://repository.unair.ac.id/123225/3/Kesesuaian_35_Erma_Safitri.pdf text en https://repository.unair.ac.id/123225/5/Similarity_35_Erma_Safitri.pdf text en https://repository.unair.ac.id/123225/4/Korespondensi_35_Erma_Safitri.pdf Abdul Samik, - and Erma Safitri, - (2017) Potency of Mycotoxin Binders on MDA Level, Expressions of Caspase 9 and Caspase 3 in The Uterus of Mice Exposed to Zearalenone. Iraqi Journal of Veterinary Sciences, 31 (1). pp. 29-33. ISSN 1607-3894 |
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SF405.5-407 Laboratory animals SF910 Other diseases and conditions Abdul Samik, - Erma Safitri, - Potency of Mycotoxin Binders on MDA Level, Expressions of Caspase 9 and Caspase 3 in The Uterus of Mice Exposed to Zearalenone |
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This study examined effect of mycotoxin binder administered to female mice exposed to zearalenon on apoptosis incidence by observe at MDA, Caspase 9 and 3 levels in mice uterus. Negative control group (K-) was not exposed to zearalenon and without the administration of mycotoxin binders, positive control group (K+) exposed to zearalenon of 0.1 mg/head/day and without the provision of mycotoxin binders; and treatment groups (P1, P2, P3) were exposed to zearalenon 0.1 mg/head/day by providing mycotoxin binders each 0.5; 1; 2 mg/head/day. Zearalenon and mycotoxinbinders administration was conducted for 10 days. Results on MDA level were as follows 15.48 ± 0.50 (K-), 45.59 ± 0.50 (K+), 34.92 ± 3.38 (P1), 27.72 ± 1.25 and 23.89 ± 3.74. Caspase 9 levels showed the following results: 0.3 ± 0.60 (K), 8.3 ± 0.90 (K+), 3.6 ± 0.41 (P1), 3.3 ± 0.34 (P2) and 2.8 ± 0.28 (P3), while the levels of Caspase3 were as follows: 3.35 ± 0.44 (K-), 12.5 ± 0.66 (K+), 3.6 ± 0.41 (P1), 4.80 ± 0.43 (P2) and 3.85 ± 0.50 (P3). In conclusion, mycotoxin binders may lower malondialdehyde (MDA) level and the expression of caspase 9 and caspase3 in the uterus of mice exposed to zearalenon. |
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Article PeerReviewed |
author |
Abdul Samik, - Erma Safitri, - |
author_facet |
Abdul Samik, - Erma Safitri, - |
author_sort |
Abdul Samik, - |
title |
Potency of Mycotoxin Binders on MDA Level, Expressions of Caspase 9 and Caspase 3 in The Uterus of Mice Exposed to Zearalenone |
title_short |
Potency of Mycotoxin Binders on MDA Level, Expressions of Caspase 9 and Caspase 3 in The Uterus of Mice Exposed to Zearalenone |
title_full |
Potency of Mycotoxin Binders on MDA Level, Expressions of Caspase 9 and Caspase 3 in The Uterus of Mice Exposed to Zearalenone |
title_fullStr |
Potency of Mycotoxin Binders on MDA Level, Expressions of Caspase 9 and Caspase 3 in The Uterus of Mice Exposed to Zearalenone |
title_full_unstemmed |
Potency of Mycotoxin Binders on MDA Level, Expressions of Caspase 9 and Caspase 3 in The Uterus of Mice Exposed to Zearalenone |
title_sort |
potency of mycotoxin binders on mda level, expressions of caspase 9 and caspase 3 in the uterus of mice exposed to zearalenone |
publisher |
University of Mosul - College of Veterinary Medicine |
publishDate |
2017 |
url |
https://repository.unair.ac.id/123225/2/Artikel_35_Erma_Safitri.pdf https://repository.unair.ac.id/123225/3/Kesesuaian_35_Erma_Safitri.pdf https://repository.unair.ac.id/123225/5/Similarity_35_Erma_Safitri.pdf https://repository.unair.ac.id/123225/4/Korespondensi_35_Erma_Safitri.pdf https://repository.unair.ac.id/123225/ |
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1764209034099949568 |