The effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice
Transfersome has been developed to enhance dermal delivery of amniotic mesenchymal stem cell metabolite products (AMSC-MP). AMSC-MP contains many growth factors for managing skin aging, thus improving the quality of an adjusted life year. This study aims to determine the effect of surfactant types a...
Saved in:
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article PeerReviewed |
Language: | English English English English |
Published: |
Informa Healthcare
2022
|
Subjects: | |
Online Access: | https://repository.unair.ac.id/123614/2/C-01%20Artikel.pdf https://repository.unair.ac.id/123614/1/C-01%20Kualitas%20Karil.pdf https://repository.unair.ac.id/123614/4/C-01%20Similarity.pdf https://repository.unair.ac.id/123614/3/C-01%20Korespondensi.pdf https://repository.unair.ac.id/123614/ https://www.tandfonline.com/doi/full/10.1080/10717544.2022.2149895 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universitas Airlangga |
Language: | English English English English |
id |
id-langga.123614 |
---|---|
record_format |
dspace |
spelling |
id-langga.1236142023-04-15T07:18:02Z https://repository.unair.ac.id/123614/ The effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice Andang Miatmoko, - Nurul Ailda Marufah, - Qothrin Nada, - Noorma Rosita, - Tristiana Erawati, - Joni Susanto, - Kusuma Eko Purwantari, - Arif Nurkanto, - Purwati, - Widji Soeratri, - R Medicine RS Pharmacy and materia medica RS1-441 Pharmacy and materia medica RS200-201 Pharmaceutical dosage forms Transfersome has been developed to enhance dermal delivery of amniotic mesenchymal stem cell metabolite products (AMSC-MP). AMSC-MP contains many growth factors for managing skin aging, thus improving the quality of an adjusted life year. This study aims to determine the effect of surfactant types acting as the edge activator on transfersome-loading AMSC-MP. Transfersome was prepared by thin-layer hydration method and composed of l-α-phosphatidylcholine as a phospholipid and three types of surfactants, namely; cationic (stearylamine), anionic (sodium cholate), and nonionic surfactant (Tween 80) at a weight ratio of 85:15, respectively. Transfersomes were evaluated for physical characteristics, penetration, effectiveness, and safety. The results showed that sodium cholate, an anionic surfactant, produced the smallest transfersome particle size, i.e., 144.2 ± 3.2 nm, among all formulas. Trans-SA containing stearylamine had a positive charge of 41.53 ± 6.03 mV compared to Trans-SC and Trans-TW, whose respective charges were –56.9 ± 0.55 mV and –41.73 ± 0.86 mV. The small particle size and low negative value of zeta potential enabled high dermal penetration by transfersomes containing AMSC-MP, while the positive charge of stearylamine hindered its penetration of deeper skin layers. Trans-SC and Trans-TW produced higher collagen density values at 77.11 ± of 4.15% and 70.05 ± of 6.95%, than that of Trans-SA. All the AMSC-MP transfersomes were relatively safe with 0.5–1.0 macrophage cell numbers invaded the dermis per field of view. In conclusion, sodium cholate, an anionic surfactant, demonstrated considerable capacity as the edge activator of transfersome-loading AMSC-MP for skin anti-aging therapy. Informa Healthcare 2022-12-05 Article PeerReviewed text en https://repository.unair.ac.id/123614/2/C-01%20Artikel.pdf text en https://repository.unair.ac.id/123614/1/C-01%20Kualitas%20Karil.pdf text en https://repository.unair.ac.id/123614/4/C-01%20Similarity.pdf text en https://repository.unair.ac.id/123614/3/C-01%20Korespondensi.pdf Andang Miatmoko, - and Nurul Ailda Marufah, - and Qothrin Nada, - and Noorma Rosita, - and Tristiana Erawati, - and Joni Susanto, - and Kusuma Eko Purwantari, - and Arif Nurkanto, - and Purwati, - and Widji Soeratri, - (2022) The effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice. Drug Delivery, 29 (1). pp. 3443-3453. ISSN 1071-7544 https://www.tandfonline.com/doi/full/10.1080/10717544.2022.2149895 10.1080/10717544.2022.2149895 |
institution |
Universitas Airlangga |
building |
Universitas Airlangga Library |
continent |
Asia |
country |
Indonesia Indonesia |
content_provider |
Universitas Airlangga Library |
collection |
UNAIR Repository |
language |
English English English English |
topic |
R Medicine RS Pharmacy and materia medica RS1-441 Pharmacy and materia medica RS200-201 Pharmaceutical dosage forms |
spellingShingle |
R Medicine RS Pharmacy and materia medica RS1-441 Pharmacy and materia medica RS200-201 Pharmaceutical dosage forms Andang Miatmoko, - Nurul Ailda Marufah, - Qothrin Nada, - Noorma Rosita, - Tristiana Erawati, - Joni Susanto, - Kusuma Eko Purwantari, - Arif Nurkanto, - Purwati, - Widji Soeratri, - The effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice |
description |
Transfersome has been developed to enhance dermal delivery of amniotic mesenchymal stem cell metabolite products (AMSC-MP). AMSC-MP contains many growth factors for managing skin aging, thus improving the quality of an adjusted life year. This study aims to determine the effect of surfactant types acting as the edge activator on transfersome-loading AMSC-MP. Transfersome was prepared by thin-layer hydration method and composed of l-α-phosphatidylcholine as a phospholipid and three types of surfactants, namely; cationic (stearylamine), anionic (sodium cholate), and nonionic surfactant (Tween 80) at a weight ratio of 85:15, respectively. Transfersomes were evaluated for physical characteristics, penetration, effectiveness, and safety. The results showed that sodium cholate, an anionic surfactant, produced the smallest transfersome particle size, i.e., 144.2 ± 3.2 nm, among all formulas. Trans-SA containing stearylamine had a positive charge of 41.53 ± 6.03 mV compared to Trans-SC and Trans-TW, whose respective charges were –56.9 ± 0.55 mV and –41.73 ± 0.86 mV. The small particle size and low negative value of zeta potential enabled high dermal penetration by transfersomes containing AMSC-MP, while the positive charge of stearylamine hindered its penetration of deeper skin layers. Trans-SC and Trans-TW produced higher collagen density values at 77.11 ± of 4.15% and 70.05 ± of 6.95%, than that of Trans-SA. All the AMSC-MP transfersomes were relatively safe with 0.5–1.0 macrophage cell numbers invaded the dermis per field of view. In conclusion, sodium cholate, an anionic surfactant, demonstrated considerable capacity as the edge activator of transfersome-loading AMSC-MP for skin anti-aging therapy. |
format |
Article PeerReviewed |
author |
Andang Miatmoko, - Nurul Ailda Marufah, - Qothrin Nada, - Noorma Rosita, - Tristiana Erawati, - Joni Susanto, - Kusuma Eko Purwantari, - Arif Nurkanto, - Purwati, - Widji Soeratri, - |
author_facet |
Andang Miatmoko, - Nurul Ailda Marufah, - Qothrin Nada, - Noorma Rosita, - Tristiana Erawati, - Joni Susanto, - Kusuma Eko Purwantari, - Arif Nurkanto, - Purwati, - Widji Soeratri, - |
author_sort |
Andang Miatmoko, - |
title |
The effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice |
title_short |
The effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice |
title_full |
The effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice |
title_fullStr |
The effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice |
title_full_unstemmed |
The effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice |
title_sort |
effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in uv-aging induced mice |
publisher |
Informa Healthcare |
publishDate |
2022 |
url |
https://repository.unair.ac.id/123614/2/C-01%20Artikel.pdf https://repository.unair.ac.id/123614/1/C-01%20Kualitas%20Karil.pdf https://repository.unair.ac.id/123614/4/C-01%20Similarity.pdf https://repository.unair.ac.id/123614/3/C-01%20Korespondensi.pdf https://repository.unair.ac.id/123614/ https://www.tandfonline.com/doi/full/10.1080/10717544.2022.2149895 |
_version_ |
1764209090842591232 |