Physical Characterization and Biodistribution of Cisplatin Loaded in Surfactant Modified-Hybrid Nanoparticles Using Polyethylene Oxide-b-Polymethacrylic Acid

• Main Author: Andang Miatmoko, -
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Tabriz University of Medical Sciences 2020
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/123626/4/C-05%20Artikel.pdf; https://repository.unair.ac.id/123626/2/C-05%20Kualitas%20Karil.pdf; https://repository.unair.ac.id/123626/3/C-05%20Similarity.pdf; https://repository.unair.ac.id/123626/1/C-05%20Korespondensi.pdf; https://repository.unair.ac.id/123626/; https://apb.tbzmed.ac.ir/Article/apb-29003; https://doi.org/10.34172/apb.2021.086
• Institution: Universitas Airlangga

Purpose: Conjugating cisplatin into hybrid nanoparticles is intended to enhance tumor accumulation in cancer therapy due to drug interaction with polymer and prevent premature drug release because of the presence of a lipid layer. Methods: Hybrid nanoparticles composed of polyethylene oxide-b-polymethacrylic acid, egg phosphatidylcholine, and surfactant, i.e. sodium cholate/sodium deoxycholate/Tween 80, were prepared by the injection method. Cisplatin was subsequently loaded by incubating the polymer-drug mixtures at the molar ratio of carboxylate ions of 2:1. Results: The results showed that the addition of surfactants produced particle sizes between 33 and 52 nm. The addition of cisplatin increased the ζ-potential to slightly positive charges with encapsulation efficiencies of 5%-18%. An in vivo biodistribution study of mice identified a cisplatin plasma concentration of sodium cholate-modified hybrid nanoparticles 10 times higher than cisplatin solution, thus producing high tumor accumulation. Conclusion: Conjugating cisplatin into sodium cholate-modified hybrid nanoparticles improves its accumulation in tumors.