The Effect of Combination Calcium Hydroxide-Propolis Application to Amount of Neutrophil Cells on Wistar Rat Pulp Perforation
Background: Pulp inflammation can be treated with pulp capping by calcium hydroxide as the gold standard. Pulp capping by calcium hydroxide could causing tissue necrosis followed by inflammation. Calcium hydroxide combined with propolis which have anti-inflammatory effects through inhibition of th...
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| Main Authors: | , , |
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| Format: | Article PeerReviewed |
| Language: | English English English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://repository.unair.ac.id/123634/1/18.pdf https://repository.unair.ac.id/123634/2/18.pdf https://repository.unair.ac.id/123634/3/18.pdf https://repository.unair.ac.id/123634/ |
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| Institution: | Universitas Airlangga |
| Language: | English English English |
| Summary: | Background: Pulp inflammation can be treated with pulp capping by calcium hydroxide as the gold standard. Pulp
capping by calcium hydroxide could causing tissue necrosis followed by inflammation. Calcium hydroxide combined with
propolis which have anti-inflammatory effects through inhibition of the Nf-kB pathway and pro-inflammatory cytokines.
That process will inhibit the increase of vascular permeability and neutrophil chemotaxis. Inflammatory process can
accelerate by controlling the amount of neutrophil cells as a acute phase marker, so the healing process occurs more
quickly. Therefore it is necessary to study the amount of neutrophil cells in the pulp perforation of Wistar rats after
applicated by combination of calcium hydroxide-propolis. Purpose: To analyze the difference amount of neutrophil cells
on the Wistar rats pulp perforation after applicated by calcium hydroxide-propolis combination compared with calcium
hydroxide-aquadest Method: M1 tooth perforated for all groups with three types tratment: no medication (control
group), calcium hydroxide-aquadest 1: 1 (P-1 group), and calcium hydroxide-propolis 1: 1.5 (P-2 group) and closed with
cention. Observations were made on the 1st, and 3rd day with HE staining. Results: One Way ANOVA shown a significant
difference (p <0.05) of the average amount of neutrophil cells between all treatment groups on 1st day (p=0.000) and 3rd
day (p=0.000). The amount of neutrophil cells in the calcium hydroxide-propolis (P-2) combination group was lower than
control group and calcium hydroxide-aquadest (P-1) group on the 1st and 3rd day. Conclusion: The amount of neutrophil
cells after application of calcium hydroxide-propolis is lower than calcium hydroxide-aquadest application. |
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