The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes

• Main Authors: Andang Miatmoko, -, Berlian Sarasitha Hariawan, -, Devy Maulidya Cahyani, -, Retno Sari, -, Aristika Dinaryanti, -, Eryk Hendrianto, -
• Format: Article PeerReviewed
• Language: English; English; English; English
• Published: Academia Brasileira de Ciências 2021
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/123683/1/C-10%20Artikel.pdf; https://repository.unair.ac.id/123683/3/C-10%20Kualitas%20Karil.pdf; https://repository.unair.ac.id/123683/4/C-10%20Similarity.pdf; https://repository.unair.ac.id/123683/2/C-10%20Korespondensi.pdf; https://repository.unair.ac.id/123683/; https://www.scielo.br/j/aabc/a/tzYtGbwHGxrbSFrgTNtgWgy/?lang=en; https://doi.org/10.1590/0001-3765202120201850
• Institution: Universitas Airlangga

This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed of span 60 and cholesterol. The results showed that the addition of chitosan increased particle sizes and ζ-potentials. The UA niosomes with chitosan layers had higher...