Increase of CD 34 in Bone Defect Healing Lesions of Periodontitis by Capsaicin Administration
The relationship between the increase of CD 34 and TRPV-1 stimulation after being given by capsaicin in bone defect healing. Twenty-one male wistar rats were disorderly divided into three categories (each category=7): the first (K0=negative control), the second (K1=positive control), and the thir...
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| Main Authors: | , , , |
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| Format: | Article PeerReviewed |
| Language: | English English English |
| Published: |
Ektodermal Displazi Grubu
2021
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| Subjects: | |
| Online Access: | https://repository.unair.ac.id/123780/1/7.pdf https://repository.unair.ac.id/123780/2/7.pdf https://repository.unair.ac.id/123780/3/7.pdf https://repository.unair.ac.id/123780/ |
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| Institution: | Universitas Airlangga |
| Language: | English English English |
| Summary: | The relationship between the increase of CD 34 and TRPV-1 stimulation after being given by
capsaicin in bone defect healing. Twenty-one male wistar rats were disorderly divided into three
categories (each category=7): the first (K0=negative control), the second (K1=positive control), and
the third (K2=treatment). Both K0 and K1 were only given with serotype b Aggregatibacter
actinomycetemcomintas (A.a) to the cervical part of area of the first molar. The K2 category was
given by serotype b A.a and cayenne pepper extract at dose 0.0912 mg/kg/day. After a week, the
rats were sacrified using thionembutal with dose 30 mg/kg in accordance with their weight and for
manufacturing sample specimen from gingival tissue region by immunology testing using
immunohistochemical method. The acquired data were contrasted using a one-way Anova test.
Result confirmed both TRPV-1 compute and CD-34 in K2 category to be prominent divergence in
both TRPV-1 and CD-34 than K1 and K0 (p<0.05), whereas there was no prominent divergence
between K1 and K0 (p>0.05). Capsaisin promotes the number of CD 34, angiogenesis factors, and
microbial agents that it can be confirmed as the alternative treatment for bone defect healing
caused by periodontitis. |
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