Anti-biofilm Activity of Epigallocatechin gallate (EGCG) against Streptococcus mutans bacteria
Dental caries is a disease caused by Streptococcus mutans. The use of chlorhexidine to inhibit bacterial colonization has side effects such as tooth staining and can kill the normal flora when used long term. Epigallocatechin gallate (EGCG) is a chemical compound in the form of polyphenols from gree...
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id-langga.1238052023-04-17T03:18:10Z https://repository.unair.ac.id/123805/ Anti-biofilm Activity of Epigallocatechin gallate (EGCG) against Streptococcus mutans bacteria Prawati Nuraini, - Mega Moeharyono Puteri, - Eksa Arinda Pramesty, - R Medicine RJ Pediatrics RK Dentistry Dental caries is a disease caused by Streptococcus mutans. The use of chlorhexidine to inhibit bacterial colonization has side effects such as tooth staining and can kill the normal flora when used long term. Epigallocatechin gallate (EGCG) is a chemical compound in the form of polyphenols from green tea catechins which have antimicrobial potency to inhibit microorganism growth and biofilm formation. Type Laboratory Experimental Research In-vitro. The group that will be studied are the negative control group in the form of S.mutans + 5% sucrose, the treatment group in the form of S. mutans + 5% sucrose and EGCG concentration of 0.125mg/ml, 0.25mg/ml, 0.375mg/ml and a positive control group is S.mutans + 5% sucrose and 0.1% chlorhexidine. Data were analyzed using the Kolmogorov-Smirnov test to determine the normality of the data, Levene's test for homogeneity of data, One Way ANOVA Post Hoc Tukey HSD Multiple Comparison to determine differences between treatments. Results: There were significant differences between the treatment groups and the negative control at test results Post Hoc Tukey HSD and the significant differences in the concentration of EGCG 0.375mg/ml with the positive control given chlorhexidine 0.1% (p <0.05). Epigallocatechin gallate (EGCG) influence on the activity of S. mutans biofilm formation and EGCG concentration of 0.375mg/ml are more effective as an antibiofilm of S. mutans compared with chlorhexidine 0.1%. A and V Publication 2021 Article PeerReviewed text en https://repository.unair.ac.id/123805/1/10.ARTIKEL.pdf text en https://repository.unair.ac.id/123805/2/10.TURNITIN.pdf text id https://repository.unair.ac.id/123805/3/10.KARIL.pdf Prawati Nuraini, - and Mega Moeharyono Puteri, - and Eksa Arinda Pramesty, - (2021) Anti-biofilm Activity of Epigallocatechin gallate (EGCG) against Streptococcus mutans bacteria. Research Journal of Pharmacy and Technology, 14 (9). pp. 5019-5023. ISSN 0974-3618, 0974-360X 10.52711/0974-360X.2021.00875 |
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Dental caries is a disease caused by Streptococcus mutans. The use of chlorhexidine to inhibit bacterial colonization has side effects such as tooth staining and can kill the normal flora when used long term. Epigallocatechin gallate (EGCG) is a chemical compound in the form of polyphenols from green tea catechins which have antimicrobial potency to inhibit microorganism growth and biofilm formation. Type Laboratory Experimental Research In-vitro. The group that will be studied are the negative control group in the form of S.mutans + 5% sucrose, the treatment group in the form of S. mutans + 5% sucrose and EGCG concentration of 0.125mg/ml, 0.25mg/ml, 0.375mg/ml and a positive control group is S.mutans + 5% sucrose and 0.1% chlorhexidine. Data were analyzed using the Kolmogorov-Smirnov test to determine the normality of the data, Levene's test for homogeneity of data, One Way ANOVA Post Hoc Tukey HSD Multiple Comparison to determine differences between treatments. Results: There were significant differences between the treatment groups and the negative control at test results Post Hoc Tukey HSD and the significant differences in the concentration of EGCG 0.375mg/ml with the positive control given chlorhexidine 0.1% (p <0.05). Epigallocatechin gallate (EGCG) influence on the activity of S. mutans biofilm formation and EGCG concentration of 0.375mg/ml are more effective as an antibiofilm of S. mutans compared with chlorhexidine 0.1%. |
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Article PeerReviewed |
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Prawati Nuraini, - Mega Moeharyono Puteri, - Eksa Arinda Pramesty, - |
author_facet |
Prawati Nuraini, - Mega Moeharyono Puteri, - Eksa Arinda Pramesty, - |
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Prawati Nuraini, - |
title |
Anti-biofilm Activity of Epigallocatechin gallate (EGCG) against Streptococcus mutans bacteria |
title_short |
Anti-biofilm Activity of Epigallocatechin gallate (EGCG) against Streptococcus mutans bacteria |
title_full |
Anti-biofilm Activity of Epigallocatechin gallate (EGCG) against Streptococcus mutans bacteria |
title_fullStr |
Anti-biofilm Activity of Epigallocatechin gallate (EGCG) against Streptococcus mutans bacteria |
title_full_unstemmed |
Anti-biofilm Activity of Epigallocatechin gallate (EGCG) against Streptococcus mutans bacteria |
title_sort |
anti-biofilm activity of epigallocatechin gallate (egcg) against streptococcus mutans bacteria |
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A and V Publication |
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2021 |
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https://repository.unair.ac.id/123805/1/10.ARTIKEL.pdf https://repository.unair.ac.id/123805/2/10.TURNITIN.pdf https://repository.unair.ac.id/123805/3/10.KARIL.pdf https://repository.unair.ac.id/123805/ |
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