Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models,
ABSTRACT Childbirth induces a number of alterations, including ligament weakening and increased vaginal distensibility. The occurrence of vaginal laxity or distensibility is associated with the vaginal wall and introitus overstretching during vaginal parturition while the pathophysiology is due t...
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id-langga.1238092023-06-25T11:09:42Z https://repository.unair.ac.id/123809/ Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models, Trisniartami Setyaningrum, Trisniartami M. Yulianto Listiawan, - Brahmana Askandar Tjokroprawiro, Brahmana Budi Santoso, Budi Cita Rosita Sigit Prakoeswa, Cita Widjiati, Widjiati R5-920 Medicine (General) ABSTRACT Childbirth induces a number of alterations, including ligament weakening and increased vaginal distensibility. The occurrence of vaginal laxity or distensibility is associated with the vaginal wall and introitus overstretching during vaginal parturition while the pathophysiology is due to increased levator dimension and trauma to the levator ani muscle through avulsion (macrotrauma) or overdistension (microtrauma). Elastin is an extracellular matrix protein that confers elastic properties to organs and tissues, particularly those requiring elasticity. Elastin plays a vital role in the functioning of numerous tissues, such as the lungs, blood vessels, heart valves, ligaments, tendons, and skin. It is also a component of the vaginal mucosa. The aim of the present was to evaluate the role of elastin in the thickening of the postpartum vaginal wall composed of epithelial mucosa, and to understand the mechanism underlying vaginal laxity or distensibility within parous and nulliparous animal models. A total of 32 female white rats (Rattus norvegicus) were used in the present study. They were divided into two groups, each group consisting of 16 rats. The control group (C0) consisted of virgin nulliparous rats, which were sacrificed on the second day after vaginal parturition. Pregnant rats (group C1) were sacrificed on the second day after vaginal parturition. The median elastin expression in group C1 was higher (3 ± 0.56) than group C0 (2.85 ± 0.75). The mean thickness of the vaginal mucosal epithelium in group C0 (56,8 931µm) was greater than group C1 (44,98 349µm). The comparison of vaginal mucosal epithelium thickness between the two groups indicated a significant difference between groups C0 and C1. Elastin levels were significantly correlated with epithelial thickness. The expression of elastin significantly affects the vaginal wall thickness, which further affects vaginal laxity or vaginal distensibility. Keywords: Distensibility, Elastin, Vaginal wall, Animals Scienceline Publication Article PeerReviewed text en https://repository.unair.ac.id/123809/1/04.%20artikel.pdf text id https://repository.unair.ac.id/123809/2/04.%20%20karil.pdf text en https://repository.unair.ac.id/123809/3/04.%20turnitin.pdf text en https://repository.unair.ac.id/123809/6/04.%20Role%20of%20Elastin%20Expression.pdf Trisniartami Setyaningrum, Trisniartami and M. Yulianto Listiawan, - and Brahmana Askandar Tjokroprawiro, Brahmana and Budi Santoso, Budi and Cita Rosita Sigit Prakoeswa, Cita and Widjiati, Widjiati Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models,. World's Veterinary Journal, 11 (2). pp. 228-234. ISSN 2322-4568 https://wvj.science-line.com/vol-11-no-2-jun-2021.html https://dx.doi.org/10.54203/scil.2021.wvj29 |
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R5-920 Medicine (General) Trisniartami Setyaningrum, Trisniartami M. Yulianto Listiawan, - Brahmana Askandar Tjokroprawiro, Brahmana Budi Santoso, Budi Cita Rosita Sigit Prakoeswa, Cita Widjiati, Widjiati Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models, |
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ABSTRACT
Childbirth induces a number of alterations, including ligament weakening and increased vaginal distensibility. The
occurrence of vaginal laxity or distensibility is associated with the vaginal wall and introitus overstretching during
vaginal parturition while the pathophysiology is due to increased levator dimension and trauma to the levator ani
muscle through avulsion (macrotrauma) or overdistension (microtrauma). Elastin is an extracellular matrix protein
that confers elastic properties to organs and tissues, particularly those requiring elasticity. Elastin plays a vital role in
the functioning of numerous tissues, such as the lungs, blood vessels, heart valves, ligaments, tendons, and skin. It is
also a component of the vaginal mucosa. The aim of the present was to evaluate the role of elastin in the thickening
of the postpartum vaginal wall composed of epithelial mucosa, and to understand the mechanism underlying vaginal
laxity or distensibility within parous and nulliparous animal models. A total of 32 female white rats (Rattus
norvegicus) were used in the present study. They were divided into two groups, each group consisting of 16 rats.
The control group (C0) consisted of virgin nulliparous rats, which were sacrificed on the second day after vaginal
parturition. Pregnant rats (group C1) were sacrificed on the second day after vaginal parturition. The median elastin
expression in group C1 was higher (3 ± 0.56) than group C0 (2.85 ± 0.75). The mean thickness of the vaginal
mucosal epithelium in group C0 (56,8 931µm) was greater than group C1 (44,98 349µm). The comparison of
vaginal mucosal epithelium thickness between the two groups indicated a significant difference between groups C0
and C1. Elastin levels were significantly correlated with epithelial thickness. The expression of elastin significantly
affects the vaginal wall thickness, which further affects vaginal laxity or vaginal distensibility.
Keywords: Distensibility, Elastin, Vaginal wall, Animals |
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Article PeerReviewed |
author |
Trisniartami Setyaningrum, Trisniartami M. Yulianto Listiawan, - Brahmana Askandar Tjokroprawiro, Brahmana Budi Santoso, Budi Cita Rosita Sigit Prakoeswa, Cita Widjiati, Widjiati |
author_facet |
Trisniartami Setyaningrum, Trisniartami M. Yulianto Listiawan, - Brahmana Askandar Tjokroprawiro, Brahmana Budi Santoso, Budi Cita Rosita Sigit Prakoeswa, Cita Widjiati, Widjiati |
author_sort |
Trisniartami Setyaningrum, Trisniartami |
title |
Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models, |
title_short |
Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models, |
title_full |
Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models, |
title_fullStr |
Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models, |
title_full_unstemmed |
Role of Elastin Expression in Thickening the Postpartum Vaginal Wall in Virgin and Postpartum Rat Models, |
title_sort |
role of elastin expression in thickening the postpartum vaginal wall in virgin and postpartum rat models, |
publisher |
Scienceline Publication |
url |
https://repository.unair.ac.id/123809/1/04.%20artikel.pdf https://repository.unair.ac.id/123809/2/04.%20%20karil.pdf https://repository.unair.ac.id/123809/3/04.%20turnitin.pdf https://repository.unair.ac.id/123809/6/04.%20Role%20of%20Elastin%20Expression.pdf https://repository.unair.ac.id/123809/ https://wvj.science-line.com/vol-11-no-2-jun-2021.html https://dx.doi.org/10.54203/scil.2021.wvj29 |
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