Concurrent benzodiazepine use in older adults treated with antidepressants in Asia
Abstract ABSTRACTBackground:Little is known about the combined use of benzodiazepines and antidepressants in older psychiatric patients. This study examined the prescription pattern of concurrent benzodiazepines in older adults treated with antidepressants in Asia, and explored its demographic and...
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Cambridge University Press
2018
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id-langga.1243682023-09-08T07:02:43Z https://repository.unair.ac.id/124368/ Concurrent benzodiazepine use in older adults treated with antidepressants in Asia Xiao-Mei Zhong Fei Wang Qinge Zhang Gabor S Ungvari Chee H Ng Helen F K Chiu Tian-Mei Si Kang Sim Ajit Avasthi Sandeep Grover Mian-Yoon Chong Kok-Yoon Chee Shigenobu Kanba Min-Soo Lee Shu-Yu Yang Pichet Udomratn Roy A Kallivayalil Andi J Tanra Margarita M Maramis Winston W Shen Norman Sartorius Rathi Mahendran Chay-Hoon Tan Naotaka Shinfuku Yu-Tao Xiang R5-920 Medicine (General) Abstract ABSTRACTBackground:Little is known about the combined use of benzodiazepines and antidepressants in older psychiatric patients. This study examined the prescription pattern of concurrent benzodiazepines in older adults treated with antidepressants in Asia, and explored its demographic and clinical correlates. Methods: The data of 955 older adults with any type of psychiatric disorders were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project. Demographic and clinical characteristics were recorded using a standardized protocol and data collection procedure. Both univariate and multiple logistic regression analyses were performed. Results: The proportion of benzodiazepine and antidepressant combination in this cohort was 44.3%. Multiple logistic regression analysis revealed that higher doses of antidepressants, younger age (<65 years), inpatients, public hospital, major comorbid medical conditions, antidepressant types, and country/territory were significantly associated with more frequent co-prescription of benzodiazepines and antidepressants. Conclusions: Nearly, half of the older adults treated with antidepressants in Asia are prescribed concurrent benzodiazepines. Given the potentially adverse effects of benzodiazepines, the rationale of benzodiazepines and antidepressants co-prescription needs to be revisited. Cambridge University Press 2018 Article PeerReviewed text en https://repository.unair.ac.id/124368/1/10.%20Concurrent%20benzodiazepin.pdf text id https://repository.unair.ac.id/124368/2/C-10.pdf text en https://repository.unair.ac.id/124368/3/10.%20Concurrent%20benzodiazepine%20use%20in%20older.pdf Xiao-Mei Zhong and Fei Wang and Qinge Zhang and Gabor S Ungvari and Chee H Ng and Helen F K Chiu and Tian-Mei Si and Kang Sim and Ajit Avasthi and Sandeep Grover and Mian-Yoon Chong and Kok-Yoon Chee and Shigenobu Kanba and Min-Soo Lee and Shu-Yu Yang and Pichet Udomratn and Roy A Kallivayalil and Andi J Tanra and Margarita M Maramis and Winston W Shen and Norman Sartorius and Rathi Mahendran and Chay-Hoon Tan and Naotaka Shinfuku and Yu-Tao Xiang (2018) Concurrent benzodiazepine use in older adults treated with antidepressants in Asia. International Psychogeriatrics, 31 (5). ISSN 1041-6102E-ISSN:1741-203X https://www.cambridge.org/core/journals/international-psychogeriatrics/article/concurrent-benzodiazepine-use-in-older-adults-treated-with-antidepressants-in-asia/1CB62970587B83C74DE61E4E39D026AF 10.1017/S1041610217002563 |
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R5-920 Medicine (General) Xiao-Mei Zhong Fei Wang Qinge Zhang Gabor S Ungvari Chee H Ng Helen F K Chiu Tian-Mei Si Kang Sim Ajit Avasthi Sandeep Grover Mian-Yoon Chong Kok-Yoon Chee Shigenobu Kanba Min-Soo Lee Shu-Yu Yang Pichet Udomratn Roy A Kallivayalil Andi J Tanra Margarita M Maramis Winston W Shen Norman Sartorius Rathi Mahendran Chay-Hoon Tan Naotaka Shinfuku Yu-Tao Xiang Concurrent benzodiazepine use in older adults treated with antidepressants in Asia |
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Abstract
ABSTRACTBackground:Little is known about the combined use of benzodiazepines and antidepressants in older psychiatric patients. This study examined the prescription pattern of concurrent benzodiazepines in older adults treated with antidepressants in Asia, and explored its demographic and clinical correlates.
Methods: The data of 955 older adults with any type of psychiatric disorders were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project. Demographic and clinical characteristics were recorded using a standardized protocol and data collection procedure. Both univariate and multiple logistic regression analyses were performed.
Results: The proportion of benzodiazepine and antidepressant combination in this cohort was 44.3%. Multiple logistic regression analysis revealed that higher doses of antidepressants, younger age (<65 years), inpatients, public hospital, major comorbid medical conditions, antidepressant types, and country/territory were significantly associated with more frequent co-prescription of benzodiazepines and antidepressants.
Conclusions: Nearly, half of the older adults treated with antidepressants in Asia are prescribed concurrent benzodiazepines. Given the potentially adverse effects of benzodiazepines, the rationale of benzodiazepines and antidepressants co-prescription needs to be revisited. |
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Article PeerReviewed |
author |
Xiao-Mei Zhong Fei Wang Qinge Zhang Gabor S Ungvari Chee H Ng Helen F K Chiu Tian-Mei Si Kang Sim Ajit Avasthi Sandeep Grover Mian-Yoon Chong Kok-Yoon Chee Shigenobu Kanba Min-Soo Lee Shu-Yu Yang Pichet Udomratn Roy A Kallivayalil Andi J Tanra Margarita M Maramis Winston W Shen Norman Sartorius Rathi Mahendran Chay-Hoon Tan Naotaka Shinfuku Yu-Tao Xiang |
author_facet |
Xiao-Mei Zhong Fei Wang Qinge Zhang Gabor S Ungvari Chee H Ng Helen F K Chiu Tian-Mei Si Kang Sim Ajit Avasthi Sandeep Grover Mian-Yoon Chong Kok-Yoon Chee Shigenobu Kanba Min-Soo Lee Shu-Yu Yang Pichet Udomratn Roy A Kallivayalil Andi J Tanra Margarita M Maramis Winston W Shen Norman Sartorius Rathi Mahendran Chay-Hoon Tan Naotaka Shinfuku Yu-Tao Xiang |
author_sort |
Xiao-Mei Zhong |
title |
Concurrent benzodiazepine use in older adults treated with antidepressants in Asia |
title_short |
Concurrent benzodiazepine use in older adults treated with antidepressants in Asia |
title_full |
Concurrent benzodiazepine use in older adults treated with antidepressants in Asia |
title_fullStr |
Concurrent benzodiazepine use in older adults treated with antidepressants in Asia |
title_full_unstemmed |
Concurrent benzodiazepine use in older adults treated with antidepressants in Asia |
title_sort |
concurrent benzodiazepine use in older adults treated with antidepressants in asia |
publisher |
Cambridge University Press |
publishDate |
2018 |
url |
https://repository.unair.ac.id/124368/1/10.%20Concurrent%20benzodiazepin.pdf https://repository.unair.ac.id/124368/2/C-10.pdf https://repository.unair.ac.id/124368/3/10.%20Concurrent%20benzodiazepine%20use%20in%20older.pdf https://repository.unair.ac.id/124368/ https://www.cambridge.org/core/journals/international-psychogeriatrics/article/concurrent-benzodiazepine-use-in-older-adults-treated-with-antidepressants-in-asia/1CB62970587B83C74DE61E4E39D026AF |
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1778170981506875392 |