Protein Encodes Plasmodium berghei Vaccine Candidates: A Review

• Main Authors: Inas Hasna Azizah, Inas, Heny Arwati, Heny, Willy Sandhika, Willy, Mufasirin, Mufasirin, Theresia Indah Budhi, Theresia
• Format: Article PeerReviewed
• Language: English; Indonesian; English; English
• Published: Faculty of Medicine and Health Sciences 2023
• Subjects: R5-920 Medicine (General)
• Online Access: https://repository.unair.ac.id/124487/1/06.%20Protein%20Encodes%20Plasmodium.pdf; https://repository.unair.ac.id/124487/2/C.-6.pdf; https://repository.unair.ac.id/124487/3/06.%20Protein%20Encodes%20Plasmodium%20berghei%20Vaccine.pdf; https://repository.unair.ac.id/124487/4/06.%20Protein%20Encodes%20Plasmodium.pdf; https://repository.unair.ac.id/124487/; https://medic.upm.edu.my/jurnal_kami/volume_19_2023/mjmhs_vol19_supp_3_february_2023-71634
• Institution: Universitas Airlangga

ABSTRACT Background: Malaria has become a serious threat in many developing countries, including Indonesia. Malaria infection without proper treatment can cause death. Plasmodium berghei (P. berghei) is a malaria parasite that mostly infects rodents, and is often used as a model for in vivo antimalarial research in mice. Giving the right vaccine can be one of the efforts to control and eliminate malaria.Objectives: The purpose of this article is to review the protein coding for P. berghei as a vaccine candidate. Review: Antibodies are components of the immune system that play a role in the humoral immune response. Expression of Pb51, P47, PbVaC, PSOP25 genes in P. berghei are selected antigens against malaria parasites, has the ability to block malaria through chemotherapy and immunoprophylaxis interventions efficiently as a potential malaria vaccine candidate. Conclusion: The protein coding for P. berghei has good antigenicity as a candidates for malaria vaccine. The mechanism of blocking the transmission of parasites to mosquitoes, induction of the functional immune system and the effectiveness of malaria vaccines require further studies.